Thymic epithelial cell apoptosis, Aire and autoimmune disease.

胸腺上皮细胞凋亡、Aire 和自身免疫性疾病。

• 批准号: nhmrc : 637332
• 负责人: A/Pr Daniel Gray
• 金额: $ 31.39万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/thymic-epithelial-cell-autoimmune-disease/76033
• 关键词: Thymic; epithelial; cell; apoptosis; Aire

Autoimmune diseases, like diabetes and multiple sclerosis are a significant disease burden. Their root cause is the failure of the immune system to distinguish between the body's own tissues and potential pathogens. We propose to study how potentially dangerous immune cells are destroyed in the thymus before they can develop. This research will significantly improve our understanding of how autoimmune diseases begin.

自身免疫性疾病，如糖尿病和多发性硬化症是一个重大的疾病负担。其根本原因是免疫系统无法区分身体自身组织和潜在病原体。我们建议研究潜在危险的免疫细胞在发育之前如何在胸腺中被破坏。这项研究将大大提高我们对自身免疫性疾病开始的理解。