The Mechanisms of Epithelial Cell Survival that Govern Thymus Function
The Mechanisms of Epithelial Cell Survival that Govern Thymus Function
批准号:
nhmrc : 1121325
负责人:
A/Pr Daniel Gray
金额:
$42.39万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31
中文摘要
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英文摘要
The thymus is an organ dedicated to the production of crucial immune cells, called T lymphocytes. Cancer treatments, such as radiation or chemotherapy, destroy thymic function and impair immune recovery in patients. We aim to uncover molecular processes that govern the life and death decisions of cells in the thymus. Our goal is to then use this information to develop treatments to protect this critical organ from damage and improve immune recovery following radiation or chemotherapy.
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会议论文
Targeting Cell Death Pathways in Immune Pathology and Cancer
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Targeting Caspase 8 in T-Cell Homeostasis and Disease
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批准号:nhmrc : 1145888
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项目类别:Project Grants
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资助金额:$82.2万
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财政年份:2018
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负责人:A/Pr Daniel Gray
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依托单位:
The Mechanisms of Epithelial Cell Survival that Govern Thymus Function
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批准号:nhmrc : GNT1121325
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项目类别:Project Grants
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资助金额:$62.1万
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财政年份:2017
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负责人:A/Pr Daniel Gray
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依托单位:
The Molecular Determinants of Immunological Tolerance
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批准号:nhmrc : 1090236
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项目类别:Career Development Fellowships
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资助金额:$31.57万
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财政年份:2015
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负责人:A/Pr Daniel Gray
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依托单位:
The Molecular Determinants of Immunological Tolerance
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批准号:nhmrc : GNT1090236
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项目类别:Career Development Fellowships
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资助金额:$45.55万
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财政年份:2015
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依托单位:
The cell death mechanisms that control regulatory T cell homeostasis
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批准号:nhmrc : 1078763
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资助金额:$38.93万
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财政年份:2015
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负责人:A/Pr Daniel Gray
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依托单位:
How Deletional and Non-Deletional Tolerance Mechanisms Integrate to Prevent Autoimmune Disease
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批准号:nhmrc : 1049724
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项目类别:Project Grants
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资助金额:$34.0万
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财政年份:2013
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负责人:A/Pr Daniel Gray
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依托单位:
Understanding the pathogenesis and heterogeneity of autoimmunity as failure of multiple steps
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批准号:nhmrc : 1009190
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项目类别:NHMRC Project Grants
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资助金额:$33.61万
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财政年份:2011
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负责人:A/Pr Daniel Gray
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依托单位:
Thymic epithelial cell apoptosis, Aire and autoimmune disease.
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批准号:nhmrc : 637332
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项目类别:NHMRC Project Grants
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资助金额:$31.39万
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财政年份:2010
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负责人:A/Pr Daniel Gray
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依托单位:
Apoptosis and Autoimmune disease
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批准号:nhmrc : 637353
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项目类别:Career Development Fellowships
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资助金额:$26.3万
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财政年份:2010
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负责人:A/Pr Daniel Gray
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依托单位:
The role of environment and innate immunity in autoimmune disease.
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批准号:nhmrc : 384336
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项目类别:Early Career Fellowships
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资助金额:$18.42万
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财政年份:2006
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负责人:A/Pr Daniel Gray
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依托单位:
海外基金