The Mechanisms of Epithelial Cell Survival that Govern Thymus Function

控制胸腺功能的上皮细胞存活机制

• 批准号: nhmrc : 1121325
• 负责人: A/Pr Daniel Gray
• 金额: $ 42.39万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-epithelial-cell-thymus-function/946720
• 关键词: Mechanisms; Epithelial; Cell; Survival; Govern

The thymus is an organ dedicated to the production of crucial immune cells, called T lymphocytes. Cancer treatments, such as radiation or chemotherapy, destroy thymic function and impair immune recovery in patients. We aim to uncover molecular processes that govern the life and death decisions of cells in the thymus. Our goal is to then use this information to develop treatments to protect this critical organ from damage and improve immune recovery following radiation or chemotherapy.

胸腺是一个致力于生产关键免疫细胞的器官，称为T淋巴细胞。癌症治疗，如放疗或化疗，破坏胸腺功能，损害患者的免疫恢复。我们的目标是揭示控制胸腺细胞生死决定的分子过程。我们的目标是利用这些信息来开发治疗方法，以保护这个关键器官免受损伤，并改善放射或化疗后的免疫恢复。