The cell death mechanisms that control regulatory T cell homeostasis

控制调节性 T 细胞稳态的细胞死亡机制

• 批准号: nhmrc : 1078763
• 负责人: A/Pr Daniel Gray
• 金额: $ 38.93万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-death-mechanisms-cell-homeostasis/518608
• 关键词: cell; death; mechanisms; control; regulatory

A central question in immunology is how to prevent destructive immune responses (e.g. autoimmune disease) and initiate productive immune responses (e.g. against cancer). A major breakthrough in this area was the discovery of special immune cells, called a Regulatory T Cells. We propose to discover the genes that determine whether these cells live and die. We will use this information to control appropriate numbers and function of Regulatory T Cells to modify the immune system.

免疫学中的一个中心问题是如何防止破坏性免疫反应(如自身免疫性疾病)和启动生产性免疫反应(如抗癌)。这一领域的一个重大突破是发现了特殊的免疫细胞，称为调节性T细胞。我们计划发现决定这些细胞是否存活和死亡的基因。我们将利用这些信息来控制调节性T细胞的适当数量和功能，以改变免疫系统。