Targeting Caspase 8 in T-Cell Homeostasis and Disease

T 细胞稳态和疾病中的靶向 Caspase 8

• 批准号: nhmrc : GNT1145888
• 负责人: A/Pr Daniel Gray
• 金额: $ 121.58万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-caspase-8-homeostasis-disease/1348725
• 关键词: Targeting; Caspase; Cell; Homeostasis; Disease

Chronic infectious diseases such as HIV, hepatitis B and tuberculosis impose a massive global health burden and new treatments are desperately needed. This proposal investigates a new approach to improve immune responses and clear chronic infections. Our multidisciplinary team will define the molecular and cellular biology underlying this approach and translate our findings by re-purposing a drug already approved for other indications in humans.

艾滋病毒、B型肝炎和结核病等慢性传染病给全球带来巨大的健康负担，迫切需要新的治疗方法。该提案研究了一种改善免疫反应和清除慢性感染的新方法。我们的多学科团队将定义这种方法背后的分子和细胞生物学，并通过重新利用已经批准用于人类其他适应症的药物来转化我们的发现。