Botanicals from Central America for Menopause

来自中美洲的更年期植物药

• 批准号: 6947935
• 负责人: GAIL B MAHADY
• 金额: $ 16.69万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6947935
• 关键词: Central America; alternative medicine; bioassay; drug discovery /isolation; folk medicine; medicinal plants; menopause; plant extracts; sign /symptom; women' s health

DESCRIPTION (provided by applicant): Menopause is a universal female experience, and is defined as cessation of menstruation for at least 12 months during the midlife period. According to the World Health Organization, by the year 2030, there will be more than 60 million postmenopausal women in the United States and 1.2 billion postmenopausal women worldwide. For many years, hormone replacement therapy (HRT) has been the gold standard for the symptomatic treatment of menopause. However, in light of the results of the Women's Health Initiative, many women are searching for alternative treatments for menopause. While, botanicals such as black cohosh, red clover and soy appear to be promising alternative therapies, recently questions of safety and efficacy have arisen. Thus, it is extremely important to focus on the research and development of other treatment alternatives for menopause. In Central American countries, specifically Guatemala and Costa Rica, women have menopausal symptoms similar to their U.S. counterparts. However, these women do not seek Western medical treatment, but use natural methods including herbal medicines to improve the quality of life in the peri- and postmenopausal periods. Hypothesis: Specific botanical extracts that have been used traditionally in Central America for the treatment menopausal symptoms will have biological activities that correspond with their traditional use. Thus, these extracts can be standardized for use in animal or human studies. Our preliminary work has indicated that there are at least twelve plant species that have been used traditionally, both in Guatemala and Costa Rica, for menopause. The objective of this investigation is to collect and extract these plant species from both countries, and test the extracts for activity in specific bioassays that are relevant to menopause. The overall goal of the proposed work is to develop standardized botanical extracts, based on the bioassay results, for the symptomatic treatment of menopause. The standardized extracts would then be used as the basis of an R01 application to assess biological activity in an animal model and or pilot human study. Successful validation and standardization of traditional plant-based medicines used to treat menopause has great significance not only for the women of Central America but the rest of the world as well.

描述（由申请人提供）：更年期是一种普遍的女性经历，定义为中年期间月经停止至少 12 个月。据世界卫生组织称，到2030年，美国将有超过6000万绝经后妇女，全球将有12亿绝经后妇女。多年来，激素替代疗法（HRT）一直是更年期对症治疗的金标准。然而，根据妇女健康倡议的结果，许多女性正在寻找更年期的替代疗法。虽然黑升麻、红三叶草和大豆等植物似乎是有前途的替代疗法，但最近出现了安全性和有效性问题。因此，专注于更年期其他治疗替代方案的研究和开发极其重要。在中美洲国家，特别是危地马拉和哥斯达黎加，女性的更年期症状与美国女性相似。然而，这些女性并不寻求西医治疗，而是使用包括草药在内的自然方法来改善围绝经期和绝经后的生活质量。假设：中美洲传统上用于治疗更年期症状的特定植物提取物将具有与其传统用途相对应的生物活性。因此，这些提取物可以标准化用于动物或人类研究。我们的初步工作表明，在危地马拉和哥斯达黎加，至少有十二种植物传统上被用于治疗更年期。这项调查的目的是从两国收集和提取这些植物物种，并在与更年期相关的特定生物测定中测试提取物的活性。拟议工作的总体目标是根据生物测定结果开发标准化植物提取物，用于更年期的对症治疗。然后，标准化提取物将用作 R01 应用的基础，以评估动物模型和/或人类试点研究中的生物活性。用于治疗更年期的传统植物药物的成功验证和标准化不仅对中美洲妇女而且对世界其他地区都具有重要意义。

项目成果

Ethnomedical research and review of Q'eqchi Maya women's reproductive health in the Lake Izabal region of Guatemala: Past, present and future prospects.

• DOI: 10.1016/j.jep.2015.12.006
• 发表时间: 2016-02-03
• 期刊: Journal of ethnopharmacology
• 影响因子: 5.4
• 作者: Michel JL;Caceres A;Mahady GB
• 通讯作者: Mahady GB

Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.

• DOI: 10.1155/2016/2574637
• 发表时间: 2016
• 期刊: BioMed research international
• 作者: Li Y;Ma H;Lu Y;Tan BJ;Xu L;Lawal TO;Mahady GB;Liu D
• 通讯作者: Liu D

Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae).

• DOI: 10.1016/j.jep.2010.03.008
• 发表时间: 2010-05-27
• 期刊: JOURNAL OF ETHNOPHARMACOLOGY
• 影响因子: 5.4
• 作者: Michel, Joanna L.;Chen, Yegao;Zhang, Hongjie;Huang, Yue;Krunic, Aleksej;Orjala, Jimmy;Veliz, Mario;Soni, Kapil K.;Soejarto, Djaja Doel;Caceres, Armando;Perez, Alice;Mahady, Gail B.
• 通讯作者: Mahady, Gail B.

Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms.

• DOI: 10.1097/gme.0b013e3181a4c76a
• 发表时间: 2009-07
• 期刊: Menopause (New York, N.Y.)
• 作者: Doyle BJ;Frasor J;Bellows LE;Locklear TD;Perez A;Gomez-Laurito J;Mahady GB
• 通讯作者: Mahady GB

Estrogenic and progestagenic effects of extracts of Justicia pectoralis Jacq., an herbal medicine from Costa Rica used for the treatment of menopause and PMS.

Justicia pectoralis Jacq.（一种来自哥斯达黎加的草药，用于治疗更年期和经前综合症）提取物的雌激素和孕激素作用。

• DOI: 10.1016/j.maturitas.2010.04.001
• 发表时间: 2010
• 期刊: Maturitas
• 影响因子: 4.9
• 作者: Locklear,TracieD;Huang,Yue;Frasor,Jonna;Doyle,BrianJ;Perez,Alice;Gomez-Laurito,Jorge;Mahady,GailB
• 通讯作者: Mahady,GailB