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Osteogenic Effects of Dietary Anthocyanins in Transgenic Medaka

转基因青鳉中膳食花青素的成骨作用

基本信息

批准号：
9034551
负责人：
GAIL B MAHADY
金额：
$ 18.62万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2018-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9034551
关键词：
Affect Age Anthocyanidin Anthocyanins Anti-Inflammatory Agents Anti-inflammatory Apoptosis Bone Development Bone Resorption Bone remodeling Cells Chronic Obstructive Airway Disease Clinical Trials Cyan Fluorescent Protein Data Diabetes Mellitus Diet Dietary intake Disease Drug Prescriptions Eating Economic Burden Elderly Exhibits Family Female Fishes Flavonoids Food Foundations Fracture Gender Gene Expression Grant Heat-Shock Response Image Imagery Japanese Killifish Label Larva Ligands Measures Menopause Messenger RNA Modeling Molecular Molecular Mechanisms of Action Natural regeneration Nature Nitroreductases Osteoblasts Osteocalcin Osteoclasts Osteogenesis Osteoporosis PTH gene Patients Phenotype Physiologic calcification Pigments Prevention strategy Process Public Health Reporter Research Resolution Resveratrol Reverse Transcriptase Polymerase Chain Reaction Safety Serious Adverse Event Societies Spinal cord injury Stress Fractures Structure Systems Biology Thick Transgenic Organisms Vertebral column Water Woman Work Zebrafish age related bone bone health bone loss bone strength fruits and vegetables in vivo in vivo imaging men novel osteoclastogenesis osteogenic overexpression prevent protective effect quantitative imaging receptor skeletal teleost fish time use translational study treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Osteoporosis is a disease that is characterized by a decrease in the thickness of bone, leading to a decrease in bone strength, resulting in fragile bones. The disease affects the elderly, primarily women, but also affects men and patients with diseases such as spinal cord injury. Treatments for osteoporosis include various prescription drugs that prevent further bone degradation, but only parathyroid hormone (PHT) treatments are able to build bone. Unfortunately due to serious adverse events PHT is given only to patients with severe osteoporosis. It is well known that people who eat a diet high in fruits and vegetables have lower rates of osteoporosis. Anthocyanins are a group of water-soluble red/blue/purple flavonoid pigments found in fruits and vegetables that also appear to have a positive impact on bone development. We will study these compounds in transgenic medaka (Oryzias latipes), a special type of fish used for skeletal research and use high-resolution imaging to determine their effects on enhancing bone formation and reducing bone loss.

描述（申请人提供）：骨质疏松症是一种以骨厚度减少为特征的疾病，导致骨强度下降，导致骨骼脆弱。该疾病影响老年人，主要是女性，但也影响男性和患有脊髓损伤等疾病的患者。骨质疏松症的治疗方法包括各种预防骨质进一步退化的处方药，但只有甲状旁腺激素 (PHT) 治疗才能增强骨质。不幸的是，由于严重的不良事件，PHT 仅适用于患有严重骨质疏松症的患者。众所周知，饮食中富含水果和蔬菜的人骨质疏松症的发病率较低。花青素是在水果和蔬菜中发现的一组水溶性红/蓝/紫色类黄酮色素，似乎对骨骼发育也有积极影响。我们将在转基因青鳉（Oryzias latipes）（一种用于骨骼研究的特殊鱼类）中研究这些化合物，并使用高分辨率成像来确定它们对增强骨形成和减少骨质流失的影响。