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Osteogenic Effects of Dietary Anthocyanins in Transgenic Medaka

转基因青鳉中膳食花青素的成骨作用

基本信息

批准号：
8891715
负责人：
GAIL B MAHADY
金额：
$ 24.31万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8891715
关键词：
Affect Age Anthocyanidin Anthocyanins Anti-Inflammatory Agents Anti-inflammatory Apoptosis Bone Development Bone Resorption Bone remodeling Cells Chronic Obstructive Airway Disease Clinical Trials Cyan Fluorescent Protein Data Diabetes Mellitus Diet Dietary intake Disease Drug Prescriptions Eating Economic Burden Elderly Exhibits Family Female Fishes Flavonoids Food Foundations Fracture Gender Gene Expression Grant Heat-Shock Response Hormones Image Imagery Japanese Killifish Label Larva Ligands Measures Menopause Messenger RNA Modeling Molecular Molecular Mechanisms of Action Natural regeneration Nature Nitroreductases Osteoblasts Osteocalcin Osteoclasts Osteogenesis Osteoporosis Parathyroid gland Patients Phenotype Physiologic calcification Pigments Prevention strategy Process Public Health Reporter Research Resolution Resveratrol Reverse Transcriptase Polymerase Chain Reaction Safety Serious Adverse Event Societies Spinal cord injury Stress Fractures Structure Systems Biology Thick Transgenic Organisms Vertebral column Water Woman Work Zebrafish age related bone bone health bone loss bone strength fruits and vegetables in vivo in vivo imaging men novel osteoclastogenesis osteogenic overexpression prevent protective effect quantitative imaging receptor expression skeletal teleost fish time use translational study treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Osteoporosis is a disease that is characterized by a decrease in the thickness of bone, leading to a decrease in bone strength, resulting in fragile bones. The disease affects the elderly, primarily women, but also affects men and patients with diseases such as spinal cord injury. Treatments for osteoporosis include various prescription drugs that prevent further bone degradation, but only parathyroid hormone (PHT) treatments are able to build bone. Unfortunately due to serious adverse events PHT is given only to patients with severe osteoporosis. It is well known that people who eat a diet high in fruits and vegetables have lower rates of osteoporosis. Anthocyanins are a group of water-soluble red/blue/purple flavonoid pigments found in fruits and vegetables that also appear to have a positive impact on bone development. We will study these compounds in transgenic medaka (Oryzias latipes), a special type of fish used for skeletal research and use high-resolution imaging to determine their effects on enhancing bone formation and reducing bone loss.

描述（由申请人提供）：骨质疏松症是一种以骨厚度减少为特征的疾病，导致骨强度降低，从而导致骨骼脆弱。这种疾病影响老年人，主要是女性，但也影响男性和患有脊髓损伤等疾病的患者。骨质疏松症的治疗包括各种处方药，防止进一步的骨降解，但只有甲状旁腺激素（PHT）治疗能够建立骨骼。不幸的是，由于严重的不良事件，PHT仅用于严重骨质疏松症患者。众所周知，饮食中富含水果和蔬菜的人患骨质疏松症的几率较低。花青素是一组水溶性红/蓝/紫色类黄酮色素，存在于水果和蔬菜中，对骨骼发育也有积极影响。我们将在转基因青鳉（Oryzias latipes）中研究这些化合物，这是一种用于骨骼研究的特殊类型的鱼，并使用高分辨率成像来确定它们对增强骨形成和减少骨丢失的影响。