Simultaneous fMRI and Electrophysiology in Visual System

申请资料(申请人提供)：本申请旨在申请拨款进行试验研究，以发展最先进的24位系统，在功能磁共振成像(FMRI)期间进行电生理记录(视觉诱发电位、局部场电位、多单位活动MU、单单位活动SU)。我们目前已经开发了一套完整的32通道和24位电生理记录系统，并在3T系统上进行了广泛的测试。此外，我们已经在3T进行了颅外EEG-fMRI联合实验，并在技术上能够进行颅内LFP-fMRI实验。最后，我们目前能够：(1)在3“1”进行最先进的清醒猴子fMRI实验。我们建议将现有系统升级到每通道30K/S采样，以及(2)开发软件和磁共振兼容的颅内电极。我们将把高分辨率清醒猴子fMRI信号与电生理信号的同步记录与一组简单但有趣的视觉实验相关联，以评估现有系统和拟议系统的质量。鉴于世界范围内缺乏可用于电生理记录的商业MR兼容系统，MRI期间用于普通电生理学的最终系统将成为视觉研究的高影响力工具。

DESCRIPTION (provided by applicant): The purpose of this application is to request funding to conduct pilot studies to develop a state-of-the-art 24-bit system for conducting electrophysiological recordings (visual evoked potentials - VEP, Local Field Potentials - LFP, Multi-Unit activity MU, Single-Unit activity SU) during functional MRI (fMRI). We currently have developed a complete 32-channel and 24-bit system for electrophysiological recording that has been extensively tested both at 3 T systems. Furthermore, we have already performed combined extracranial EEG-fMRI experiments at 3T and are technically able to perform intracranial LFP-fMRI experiments. Finally, we are currently able: (1) to perform state-of-the-art awake monkey fMRI experiments at 3"1". We propose to upgrade the existing system to attain 30kS/s sampling per channel, and (2) develop software and MRI compatible intracranial electrodes. We will correlate the high-resolution awake monkey fMRI signals with the simultaneous recording of electrophysiological signals with a set of simple but interesting visual experiments to evaluate the quality of both the existing and the proposed systems. The final system for general electrophysiology during MRI will become a high impact tool for vision research, given the worldwide lack of commercially available MR-compatible systems for electrophysiological recording.