Geodesic EEG System

测地线脑电图系统

• 批准号: 8247526
• 负责人: GIORGIO BONMASSAR
• 金额: $ 20.23万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8247526
• 关键词: Anesthesia procedures; Area; Auditory; Behavioral; Brain; Brain Neoplasms; Clinical; Clinical Research; Communities; Detection; Devices; Electroencephalography; Epilepsy; Event; Feedback; Functional Magnetic Resonance Imaging; Funding; Human; Image; Image-Guided Surgery; Light; Magnetic Resonance Imaging; Measurement; Monitor; Neurosciences Research; Patients; Performance; Physiological; Process; Research; Resolution; Schizophrenia; Signal Transduction; Sleep; System; Technology; Time; Translational Research; bioimaging; blood oxygenation level dependent response; density; feeding; hemodynamics; improved; indexing; information processing; instrument; novel; research study; response; selective attention

DESCRIPTION (provided by applicant): This proposal seeks funding to purchase a novel high-performance MR-compatible EEG device for high- density and real-time EEG/fMRI studies for the Athinoula A. Martinos Center for Biomedical Imaging. From among the commercially available EEG systems we have selected the one that would provide optimal SNR and allow for high-resolution EEG recording at MRI fields up to 3T. Concurrent EEG/fMRI provides high temporal and spatial resolution needed for clinical and translational research applications. For instance, the high SNR provided by the combination of these technologies will allow improved epileptogenic foci detection using single-event BOLD response; it will also enable monitoring of brain function during sleep, under anesthesia, and during image-guided surgeries for brain tumor. Combined EEG/fMRI wil also improve basic neuroscience research. In particular, the Instrument can be used to help determine how different areas of the human brain interact during information processing to elucidate inferring cortical feed-forward vs. feedback processes in the human brain. Furthermore, the instrument will allow studies of dynamic imaging of oscillatory brain networks controlling selective attention in auditory tasks. Additionally, this technology may shed light on the relation between hemodynamic and electrophysiological indices of error processing in behavioral response. Overall, this instrument will provide a unified computational and hardware framework for real-time concurrent EEG/fMRI measurements that can be used in both research studies and, eventually, clinical patient management. Hence, use of this system by our large and growing PHS-funded research community will have important implications for studies that aim to understand the interactions between electrical and BOLD signal in normal brain function, and how they change under pathological conditions such as epilepsy and schizophrenia, and under altered physiological states such as sleep and anesthesia. PUBLIC HEALTH RELEVANCE: The proposed EEG/fMRI system and related technologies will help understanding where and when pathological brain activity occurs in diseases such as epilepsy and Schizophrenia. This system will also enable brain monitoring under anesthesia, and for basic neuroscience studies.

描述（由申请人提供）：该提案寻求资金，以购买一种新型高性能MR兼容EEG设备，用于Athinoula A的高密度和实时EEG/fMRI研究。Martinos生物医学成像中心。从市售的EEG系统中，我们选择了一个可以提供最佳SNR并允许在高达3 T的MRI场进行高分辨率EEG记录的系统。并发EEG/fMRI提供了临床和转化研究应用所需的高时间和空间分辨率。例如，这些技术的组合提供的高SNR将允许使用单事件BOLD响应来改进致痫灶检测;它还将能够在睡眠期间、麻醉下和脑肿瘤的图像引导手术期间监测脑功能。EEG/fMRI的结合也将促进基础神经科学研究。特别是，该仪器可用于帮助确定人脑的不同区域在信息处理过程中如何相互作用，以阐明人脑中皮质前馈与反馈过程的推断。此外，该仪器将允许在听觉任务中控制选择性注意的振荡脑网络的动态成像研究。此外，该技术可能揭示的血流动力学和电生理指标之间的关系的错误处理的行为反应。总的来说，该仪器将提供一个统一的计算和硬件框架，实时并发EEG/fMRI测量，可用于研究研究，并最终，临床患者管理。因此，我们庞大且不断增长的PHS资助研究社区使用该系统将对旨在了解正常大脑功能中电信号和BOLD信号之间相互作用的研究产生重要影响，以及它们在癫痫和精神分裂症等病理条件下以及在睡眠和麻醉等生理状态改变下如何变化。 公共卫生相关性：拟议中的EEG/fMRI系统和相关技术将有助于了解癫痫和精神分裂症等疾病中病理性大脑活动发生的位置和时间。该系统还将实现麻醉下的大脑监测，并用于基础神经科学研究。