Deep Brain Stimulation System for Magnetic Resonance Imaging

用于磁共振成像的深部脑刺激系统

• 批准号: 8605940
• 负责人: GIORGIO BONMASSAR
• 金额: $ 65.62万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8605940
• 关键词: Accidents; Achievement; Address; Animals; Artificial cardiac pacemaker; Behavioral; Biocompatible; Brain; Clinical; Coiled Bodies; Communication; Comorbidity; Data; Deep Brain Stimulation; Development; Diagnosis; Diagnostic; Disease; Distal; Dystonia; Effectiveness; Electrodes; Electroencephalography; Electromagnetics; Epilepsy; Fiber; Film; Fracture; Frequencies; Future; Gel; Goals; Gold; Head; Heating; Histology; Human; Immune response; Implant; Injection of therapeutic agent; Injury; Lead; Lesion; Magnetic Resonance Imaging; Major Depressive Disorder; Malignant Neoplasms; Measurement; Measures; Mechanics; Metals; Modeling; Monkeys; Morphologic artifacts; Motor; Movement; Obsessive-Compulsive Disorder; Operative Surgical Procedures; Outcome; Parkinson Disease; Patients; Perfusion; Physiologic Thermoregulation; Physiological; Polymers; Property; Radio; Rattus; Reaction Time; Refractory; Reporting; Research; Research Design; Resistance; Rodent; Safety; Source; Stroke; Structure of subthalamic nucleus; System; Technology; Tensile Strength; Testing; Theft; Thick; Time; Tissues; Translations; Trauma; United States Food and Drug Administration; Validation; absorption; base; biomaterial compatibility; brain tissue; clinical application; comparative efficacy; design; dielectric property; experience; implantation; improved; innovation; liquid crystal polymer; medical implant; medical schools; neural prosthesis; new technology; nonhuman primate; novel; public health relevance; radiofrequency; relating to nervous system; research study; simulation; success; tool

DESCRIPTION (provided by applicant): Despite its remarkable success, one of the significant limitations of Deep Brain Stimulation (DBS) is its incompatibility with magnetic resonance imaging (MRI). In this application we propose to design, develop and test novel MRI conditional leads based on resistive tapered stripline technology. The innovative high-resistance technology will allow for decreased Specific Absorption Rate and reducing artifacts of the MRI data while maintaining low lead resistivity for continuous current injection. Electromagnetic numerical simulation will be used to support the design and will be tested thoroughly on healthy animals for biocompatibility and validation. The long-term goal of this project is the development of the DBS systems compatible with MRI and other external radiofrequency sources, with significant benefits to patients that may require neural implantations in pathological conditions such as Parkinson's disease, epilepsy, and stroke.

描述(由申请人提供)： 尽管深部脑刺激(DBS)取得了显著的成功，但它的一个重大局限性是与磁共振成像(MRI)不兼容。在这一应用中，我们建议设计、开发和测试基于阻性渐变带状线技术的新型MRI条件导联。创新的高阻技术将允许降低比吸收率，减少磁共振数据的伪影，同时保持持续电流注入的低铅电阻率。电磁数值模拟将用于支持设计，并将在健康动物身上进行彻底测试，以进行生物兼容性和验证。该项目的长期目标是开发与MRI和其他外部射频源兼容的DBS系统，为可能需要在帕金森病、癫痫和中风等病理条件下植入神经的患者带来显著好处。