Intracranial Micro Magnetic Stimulation of the Frontal Eye Field in Monkeys

猴子额眼场的颅内微磁刺激

• 批准号: 7962459
• 负责人: GIORGIO BONMASSAR
• 金额: $ 22.8万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7962459
• 关键词: Affect; Area; Attention; Automobile Driving; Beds; Behavioral; Brain; Brain region; Development; Devices; Dimensions; Electric Stimulation; Electrodes; Electrophysiology (science); Feedback; Film; Functional Magnetic Resonance Imaging; Human; Image; Implant; Magnetic Resonance Imaging; Magnetism; Measurable; Mechanics; Methods; Microscopic; Monkeys; Morphologic artifacts; Motor; Neurons; Occipital lobe; Pattern; Performance; Photic Stimulation; Physiologic pulse; Population; Protocols documentation; Research; Role; Saccades; Sensory Process; Series; Signal Transduction; Site; Source; Stimulus; Structure; System; Technology; Testing; Tissues; Training; Transcranial magnetic stimulation; Visual; Visual Pathways; abstracting; awake; base; brain tissue; cost; design; electrical microstimulation; extrastriate visual cortex; frontal eye fields; lateral intraparietal area; magnetic field; neural stimulation; neuronal excitability; new technology; nonhuman primate; novel; relating to nervous system; response; success; visual stimulus

DESCRIPTION (provided by applicant): In this application we propose to design, develop and test novel MRI compatible Micro Magnetic Brain Stimulation "MMBS" methods in awake behaving monkeys. These devices will be implanted in the frontal eye field (FEF) of non-human primates. Magnetic micro-stimulation of FEF is expected to elicit spatially-specific behavioral responses in terms of saccadic eye movements and to modulate visually-driven activity in occipital cortex. Compared to traditional electrical microstimulation (EM), 5MBS can be used to increase (single pulse stimulation) or decrease (repeated theta-burst stimulation) excitability of neuronal tissue. Hence we can investigate the causal functional and behavioral consequences of nearly identical focal activations and de-activations of small portions of the FEF. Moreover, as the probes can be completely insulated from the brain tissue, we expect to record artifact-free neuronal activity in functionally connected sites during 5MBS. Finally, as Transcranial Magnetic Stimulation (TMS) is presently the method of choice to investigate causal functional interactions across brain regions in the human, 5MBS will bridge the gap between human and monkey effective connectivity studies. PUBLIC HEALTH RELEVANCE: The proposed research aims at the stimulation of the Frontal Eye Field in Monkeys with a microscopic magnetic field which allows simultaneous artifact-free electrophysiological recordings during stimulation. The development of such novel technology will result in significant advances in understanding causal and behavioral and functional consequences throughout the brain induced by focal increased and decreased activity of the FEF.

描述(由申请人提供)：在这项申请中，我们建议设计、开发和测试新的MRI兼容的微型脑刺激(MMBS)方法，用于清醒行为的猴子。这些装置将被植入非人类灵长类动物的前部眼场(FEF)。磁微刺激FEF有望在眼球跳动方面引起空间特异性的行为反应，并调节枕叶皮质的视觉驱动活动。与传统的电刺激(EM)相比，5MBS可用于增加(单脉冲刺激)或降低(重复电刺激)神经元组织的兴奋性。因此，我们可以研究FEF的一小部分几乎相同的焦点激活和去激活的因果、功能和行为后果。此外，由于探针可以与脑组织完全绝缘，我们希望在5MBS期间记录功能连接部位的无伪影神经元活动。最后，由于经颅磁刺激(TMS)是目前研究人类大脑区域之间因果功能相互作用的首选方法，5MBS将弥合人类和猴子有效连接研究之间的差距。 与公众健康相关：这项拟议的研究旨在用微型磁场刺激猴子的额叶眼场，从而在刺激过程中同时进行无伪迹的电生理记录。这种新技术的发展将导致在理解FEF局部活动增加和减少引起的整个大脑的因果以及行为和功能后果方面取得重大进展。