How the environment and epigenetics affect the brain disease gene, MAPT.

环境和表观遗传学如何影响脑部疾病基因 MAPT。

• 批准号: nhmrc : 1021269
• 负责人: A/Pr John Kwok
• 金额: --
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/environment-epigenetics-affect-gene-mapt/662332
• 关键词: How; environment; epigenetics; affect; brain

Genetic variants in the microtubule associated protein Tau (MAPT) gene are major risk factors for Alzheimer’s disease and Parkinson’s disease. Environmental or lifestyle factors, such as diet and smoking, have crucial roles in changing the risk of developing these diseases. These environmental factors may exert their influence via a mechanism known as "epigenetics". This project aims to determine whether the MAPT gene is susceptible to epigenetic changes by environmental factors, and whether this process will have an impact on these diseases.

微管相关蛋白Tau（MAPT）基因的遗传变异是阿尔茨海默病和帕金森病的主要危险因素。环境或生活方式因素，如饮食和吸烟，在改变患这些疾病的风险方面起着至关重要的作用。这些环境因素可能通过一种称为“表观遗传学”的机制发挥其影响。该项目旨在确定MAPT基因是否易受环境因素的表观遗传变化的影响，以及这一过程是否会对这些疾病产生影响。