How the environment and epigenetics affect the brain disease gene, MAPT.
How the environment and epigenetics affect the brain disease gene, MAPT.
批准号:
nhmrc : 1021269
负责人:
A/Pr John Kwok
金额:
$0.0万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2012-12-31
中文摘要
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英文摘要
Genetic variants in the microtubule associated protein Tau (MAPT) gene are major risk factors for Alzheimer’s disease and Parkinson’s disease. Environmental or lifestyle factors, such as diet and smoking, have crucial roles in changing the risk of developing these diseases. These environmental factors may exert their influence via a mechanism known as "epigenetics". This project aims to determine whether the MAPT gene is susceptible to epigenetic changes by environmental factors, and whether this process will have an impact on these diseases.
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