The Leucine Rich Repeat Kinase 1 and 2 Genes are Modulators of Alternative Splicing - Implication for Neurodegeneration

富含亮氨酸的重复激酶 1 和 2 基因是选择性剪接的调节剂 - 对神经退行性疾病的影响

• 批准号: nhmrc : 510218
• 负责人: A/Pr John Kwok
• 金额: $ 38.93万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/leucine-rich-repeat-implication-neurodegeneration/95674
• 关键词: Leucine; Rich; Repeat; Kinase; Genes

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common causes of dementia and neurodegeneration. Through positional cloning, we have identified the leucine rich repeat kinase (LRRK1) 1 gene as a modulator of alternative splicing. We have subsequently shown that its homologue, LRRK2 has a similar biological activity. We propose to study the the genetic and biochemical role of LRRK1 and LRRK2 in neurodegeneration in terms of its effect in splicing.

阿尔茨海默病（AD）和帕金森病（PD）是痴呆和神经退行性疾病的两个常见原因。通过定位克隆，我们鉴定出富含亮氨酸重复激酶 (LRRK1) 1 基因作为选择性剪接的调节剂。我们随后证明其同源物 LRRK2 具有相似的生物活性。我们建议根据其剪接效应来研究 LRRK1 和 LRRK2 在神经退行性变中的遗传和生化作用。