Biological Characterisation of the Opiod Receptor Sigma 1 Gene in the Frontotemporal Dementia and Motor Neuron Disease
Biological Characterisation of the Opiod Receptor Sigma 1 Gene in the Frontotemporal Dementia and Motor Neuron Disease
批准号:
nhmrc : 510217
负责人:
A/Pr John Kwok
金额:
$32.02万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
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英文摘要
Frontotemporal dementia (FTD) and motor neuron disease (MND) are the two common causes of dementia and neurodegeneration. We have identified a new genes that causes familial FTD and MND in pedigrees affected with dementia and-or MND.This project will study the expression and function of this new FTD-MND gene to determine its role in the aetiology and pathology of this complex of neurodegenerative disorders.
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会议论文
BRAIN-MEND: Biological Resource Analysis to Identify new mechanisms and phenotypes in Neurodegenerative Diseases
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批准号:nhmrc : GNT1151854
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项目类别:Boosting Dementia Research Initiative
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资助金额:$85.0万
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财政年份:2018
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负责人:A/Pr John Kwok
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依托单位:
The role of mutant CYLD in frontotemporal dementia and motor neuron disease
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批准号:nhmrc : GNT1140708
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项目类别:Project Grants
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资助金额:$96.32万
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财政年份:2018
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负责人:A/Pr John Kwok
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依托单位:
Non-Alzheimer’s disease degenerative dementias: Identifying prodromal genetic/familial phenotypes, modifying factors, and protein variations involved in progression
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批准号:nhmrc : GNT1095127
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项目类别:Boosting Dementia Research Initiative
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资助金额:$644.92万
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财政年份:2015
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负责人:A/Pr John Kwok
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依托单位:
Non-Alzheimer’s disease degenerative dementias: Identifying prodromal genetic/familial phenotypes, modifying factors, and protein variations involved in progression
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批准号:nhmrc : 1095127
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项目类别:Targeted Calls
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资助金额:$451.3万
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财政年份:2015
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负责人:A/Pr John Kwok
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依托单位:
Identification of dementia and motor neuron disease genes
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批准号:nhmrc : GNT1062539
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项目类别:Project Grants
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资助金额:$62.06万
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财政年份:2014
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负责人:A/Pr John Kwok
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依托单位:
Mutations in ubiquitin proteasome pathway genes as a cause of frontotemporal dementia and motor neuron disease
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批准号:nhmrc : 1062539
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项目类别:Project Grants
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资助金额:$42.67万
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财政年份:2014
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负责人:A/Pr John Kwok
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依托单位:
How the environment and epigenetics affect the brain disease gene, MAPT.
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批准号:nhmrc : 1021269
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项目类别:Project Grants
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资助金额:$0.0万
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财政年份:2012
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负责人:A/Pr John Kwok
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依托单位:
The Leucine Rich Repeat Kinase 1 and 2 Genes are Modulators of Alternative Splicing - Implication for Neurodegeneration
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批准号:nhmrc : 510218
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项目类别:NHMRC Project Grants
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资助金额:$38.93万
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财政年份:2008
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负责人:A/Pr John Kwok
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依托单位:
Identification and characterisation of phenotypic modifier genes in familial Alzheimer's disease
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批准号:nhmrc : 276401
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项目类别:NHMRC Project Grants
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资助金额:$27.56万
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财政年份:2004
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负责人:A/Pr John Kwok
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依托单位:
Alzheimer's disease and Dementia with Lewy bodies: How different are they?
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批准号:nhmrc : 300400
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项目类别:NHMRC Project Grants
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资助金额:$37.71万
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财政年份:2004
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负责人:A/Pr John Kwok
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依托单位:
Identification and Characterisation of Causative and Modifier Genes Involved in Variant Forms of Alzheimer's Disease
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批准号:nhmrc : 230862
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项目类别:Career Development Fellowships
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资助金额:$29.04万
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财政年份:2003
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负责人:A/Pr John Kwok
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依托单位:
海外基金