Extramural Research Facilities Construction

描述(由申请人提供)： 这项提议的目标是为人类疾病和复杂特征的遗传学方面的综合机构计划提供支持。没有比现在更适合这项工作的时候了：人类基因组测序方面的进展与临床数据集可用性的增加相结合，现在正准备利用分子生物学、计算科学以及流行病学和统计学原理的能力进行整合。这些方法将产生关于人类健康和疾病的遗传基础的重要信息，这将加强对疾病的诊断和治疗，并推进新靶点和药物的发现。这一目标与NIH路线图的三大主题完全一致：将新的科学途径应用于发现、临床和基础研究的整合以及组建跨学科研究团队。 宾夕法尼亚大学医学院是美国首屈一指的生物医学研究机构。宾夕法尼亚州立大学显然有能力在这一努力中取得成功，因为学校和卫生系统在领导和业务层面上都得到了充分的整合。为了实现我们的目标，我们建议通过成立人类遗传学和复杂性状中心，将临床和分子信息学方面的关键跨学科专业知识与流行病学和统计遗传学的方法论结合起来。该中心将位于Blocklev Hall新装修的空间(格林威治标准时间10,724)。该中心的主要任务是将这一综合方法应用于四个以疾病为基础的主题，并培训具有跨学科专业知识的新科学家。

DESCRIPTION (provided by applicant): The goal of this proposal is to develop support for an integrated institutional program on the genetics of human disease and complex traits. There is no more opportune time for this effort than the present: the combination of advances in sequencing the human genome and the increased availability of clinical datasets is now poised for integration using the capacities of molecular biology, computational sciences, and epidemiological and statistical principles. These approaches will generate important information on the genetic basis of human health and disease, which will enhance the diagnosis and therapy of disease, and advance the discovery of new targets and drugs. This goal is perfectly aligned with the three major themes of the NIH Roadmap: application of new scientific pathways to discovery, integration of clinical and basic research, and formation of interdisciplinary research teams. The University of Pennsylvania School of Medicine is one of the nation's premier biomedical research institutions. Penn is distinctly positioned to achieve success in this effort as the School and Health System are fully integrated at both leadership and operational levels. To achieve our goal we propose to unite critical interdisciplinary expertise in clinical and molecular informatics, with the methodologies of epidemiology and statistical genetics by formation of the Center for Human Genetics and Complex Traits. The Center will be located in newly renovated space (10,724 gsf) in Blocklev Hall. The primary missions of the Center are to apply this integrated approach across four disease-based themes, and to train new scientists with cross-disciplinary expertise.