Translational Research at PENN: Advancing Cures through Interdisciplinary Science

PENN 的转化研究：通过跨学科科学推进治疗

• 批准号: 7879184
• 负责人: Glen N. Gaulton
• 金额: $ 1299.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-18 至 2013-03-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7879184
• 关键词: Address; Award; Basic Science; Behavior; Biology; Businesses; Cancer Biology; Cardiovascular system; Chronobiology; Clinical; Clinical Investigator; Development; Disease; Equipment; Extramural Activities; Extramural Research Facilities Construction Project; Faculty; Floor; Fostering; Funding; Grant; Health behavior; Housing; Human; Inpatients; Location; Medicine; Metabolism; Minority; Mission; Molecular; Occupations; Outpatients; Pennsylvania; Physicians; Physiology; Program Development; Research; Research Support; Schedule; Science; Scientist; Silver; Site; Translational Research; Translations; Universities; clinical application; clinical care; clinical practice; cost; design; gene discovery; improved; member; multidisciplinary; programs; research facility; square foot; technology/technique

DESCRIPTION (provided by applicant): The University of Pennsylvania proposes to catalyze the formation of the PENN Center for Chronobiology through construction of 46,204 gross square feet (gsf) of contiguous space in the Fisher Translational Research Building, thereby uniting basic scientists studying biology and physiology with clinical investigators addressing the impact of chronobiology on human behavior and health. The Fisher Building, a new 405,000 gsf translational research facility scheduled for completion in late 2010, will house multidisciplinary, disease- focused research initiatives in metabolism, cardiovascular biology and cancer. Directly connected to our main inpatient and outpatient clinical facilities, the site is the focal point for translational research led by PENN's CTSA, truly integrating clinical practice with bench science by bringing scientists and physicians together under one roof to exchange ideas on new discoveries, techniques, and technologies. Because of funding limitations, only three of five research floors of the new Fisher Building are currently approved for completion. This proposal seeks funds to complete one additional floor to be designed by and used in support of the Center for Chronobiology. This new Center will unite and augment PENN's outstanding team of interdisciplinary scientists and physicians who have a unique breadth of world-wide expertise in chronobiology. This expertise spans the discovery of genes and molecular mechanisms fundamental to clock function, and encompasses behavior as well as normal physiology and disease mechanisms. Awarding this project enables PENN to coalesce 18 center scholars in a single location, catalyzing formation of the Center and integrating the Center with other research and clinical programs in the Fisher Building. Overall, the proposal will support the research mission of 57 Center members with a total of $155M in active and pending extramural support. The Center will foster new interdisciplinary program and trainee development, target faculty recruitment and guide clinical application, thereby promoting the translation of basic science to improved clinical care. In support of the ARRA, construction on this LEED Silver certified project could initiate immediately upon award issue and design approval. 430 new jobs will be created, supporting both national and local businesses, with a commitment to engaging 20-27% minority company participation. As our highest institutional priority among C06 construction projects, PENN Medicine is prepared to match the C06 award with $18 million of institutional support in construction project costs beyond those provided by the grant, for expanded faculty recruitment and program development, and in moving and new equipment occupancy expenses.

描述（由申请人提供）：宾夕法尼亚大学提议通过在费舍尔转化研究大楼建造46，204总平方英尺（gsf）的连续空间来促进宾夕法尼亚大学时间生物学中心的形成，从而将研究生物学和生理学的基础科学家与临床研究人员联合起来，解决时间生物学对人类行为和健康的影响。费舍尔大楼是一个新的405，000 gsf的转化研究设施，计划于2010年底完工，将容纳多学科，以疾病为重点的研究计划，在代谢，心血管生物学和癌症。该网站直接连接到我们的主要住院和门诊临床设施，是由PENN的CTSA领导的转化研究的焦点，通过将科学家和医生聚集在一个屋檐下交流新发现，技术和技术的想法，真正将临床实践与实验室科学相结合。由于资金限制，新费舍尔大楼的五个研究楼层中只有三个目前获准完工。该提案寻求资金来完成一个额外的楼层，由时间生物学中心设计并用于支持该中心。这个新的中心将团结和增强宾夕法尼亚大学杰出的跨学科科学家和医生团队，他们在时间生物学方面拥有独特的全球专业知识。该专业知识涵盖了对生物钟功能至关重要的基因和分子机制的发现，并涵盖了行为以及正常生理和疾病机制。授予这个项目使宾夕法尼亚大学能够在一个单一的位置合并18个中心的学者，催化中心的形成，并将中心与费舍尔大楼的其他研究和临床项目相结合。总的来说，该提案将支持57个中心成员的研究使命，总金额为1.55亿美元，用于积极和待定的校外支持。该中心将促进新的跨学科项目和培训人员的发展，有针对性的教师招聘和指导临床应用，从而促进基础科学的翻译，以改善临床护理。为了支持ARRA，这个LEED银认证项目的建设可以在授予和设计批准后立即开始。将创造430个新的就业机会，支持国家和地方企业，并承诺让20-27%的少数民族公司参与。作为我们在C 06建设项目中的最高机构优先事项，PENN Medicine准备将C 06奖与1800万美元的机构支持相匹配，这些机构支持的建设项目成本超出了赠款提供的成本，用于扩大教师招聘和项目开发，以及移动和新设备占用费用。