Neuropathology Core

神经病理学核心(核心C)的主要目标是安排和执行尸检，并为临床核心为未来尸检登记的受试者提供神经病理诊断，并维护一个具有良好特征的死后人脑组织的储存库(大脑资源中心)，用于研究帕金森氏病(PD)和路易体病(LBD)的病因和基本机制。这些组织对于验证由细胞生物学和生物化学研究产生的假说和观察是必不可少的。 项目1-4中提出的基因工程小鼠。核心C还将维护和配备工作人员 组织学/免疫细胞化学和体视学实验室，支持和便利与项目1-4所述帕金森病研究相关的人类和实验小鼠模型的形态评估。最后，Core的工作人员将在与帕金森病相关的临床和神经病理学问题上培训基础研究人员和临床神经学家。C核心的工作人员在安排和进行身体解剖、解剖和准备方面有经验 用于神经退行性疾病的研究方案、神经病理学诊断、形态研究和定量形态测量的人脑组织。为了实现其目标，Core C将为脑资源中心(BRC)、组织学/免疫细胞化学(ICC)实验室和定量形态测量/体视学设施配备和维护人员。BRC是为研究准备的固定和冰冻脑组织的储存库，包括帕金森病、其他LBD病例以及正常和疾病对照。通过其许多功能和设施，Core C将支持和协调人类死后脑组织材料的加入，这对研究帕金森氏病的基本机制至关重要，并促进项目1-4中的实验动物的形态评估。

The chief goals of the Neuropathology Core (Core C) are to arrange and perform autopsies and provide neuropathological diagnoses in subjects enrolled by the Clinical Core for prospective autopsy, and to maintain a repository (Brain Resource Center) of well-characterized postmortem human brain tissue for investigations of the etiology and basic mechanisms of Parkinson's disease (PD) and Lewy body diseases (LBD). These tissues will be essential to validate the hypotheses and observations generated by the cell biology and biochemical studies of genetically engineered mice proposed in Projects 1-4. Core C will also maintain and staff histology/immunocytochemistry and stereology laboratories to support and facilitate the morphological assessment of human and experimental mouse models relevant to the studies of PD delineated in Projects 1-4. Finally, the staff of Core will train basic investigators and clinical neuroscientists in clinical and neuropathology issues relevant to PD. The staff of Core C has experience with the arrangement and conduction of autopsies, dissection and preparation of human brain tissues for research protocols, neuropathological diagnoses, morphological studies, and quantitative morphometry of neurodegenerative disorders. To accomplish its goals, Core C will staff and maintain the Brain Resource Center (BRC), a histology/immunocytochemistry (ICC) laboratory, and a quantitative morphometry/stereology facility. The BRC serves as a repository of fixed and frozen brain tissues prepared for research including cases of PD, other LBD, and normal and diseased controls. Through its many functions and facilities, Core C will support and coordinate the accession of human postmortem brain tissue material critical for studies of the basic mechanisms underlying Parkinson's disease and facilitate the morphological assessments of experimental animals from Projects 1-4.