NEUROPATHOLOGY CORE

神经病理学核心是JHMI ADRC的核心组成部分。世界银行的工作人员 神经病理学核心公司将安排和进行尸检，对人类受试者进行神经病理学评估，并协助评估与阿尔茨海默病相关的基因工程动物模型。为了支持需要人类死后组织的研究(JHMI和合作机构)，该核心D运营着一个大脑资源中心(BRC)，这是一个固定和冷冻尸检组织的储存库。此外，该学院在培训基础科学家和内科医生有关衰老和神经退行性疾病的病理学方面发挥着关键作用，就痴呆症病例咨询外部病理学家，并进行基因分型。 与阿尔茨海默病(AD)相关。根据过去的经验，我们预计在下一个资金周期将有大量的对照组、轻度认知障碍(MCI)病例和AD患者进行尸检。此外，在下一个供资周期，将通过接触独特的个人队列，启动对血管性痴呆高危患者的尸检研究，其中一些人接受了冠状动脉旁路移植(CABG)。在下一个资助周期中，受试者的组织将不仅在JHMI ADRC内用于研究，而且将提供给合作机构的AD调查人员。该核心还将支持转基因和基因靶向小鼠的形态研究，这些小鼠旨在研究阿尔茨海默病的发病机制和治疗策略。这些分析需要详细的形态研究和体视学研究，该核心将为此目的提供一个组织学实验室和体视学单位。通过这些多项活动，本核心将协调和促进 与阿尔茨海默病相关的临床和实验组织的神经病理学评估，从而极大地提高了与ADRC相关的研究人员的诊断和研究能力。

The Neuropathology Core is a cental component of the JHMI ADRC. The staff of the Neuropathology Core will arrange and conduct autopsies, perform neuropathological evaluations of human subjects and assist in the assessment of genetically engineered animal models relevant to AD. To support research that requires postmortem tissue from humans (both at JHMI and at collaborating institutions) this core D operates a Brain Resource Center (BRC), a repository of fixed and frozen autopsy tissues. In addition, the faculty play a critical role in training basic scientists and physicians in the pathology of aging and neurodegenerative disease, consults with outside pathologists on cases of dementia, and does genotyping relevant to Alzheimers Disease (AD). Based on past experience, we anticipate that large numbers of controls, cases with Mild Cognitive Impairment (MCI) and patients with AD will come to autopsy in the next funding cycle. In addition, in the next funding cycle, autopsy studies of patients at high risk for vascular dementia will be initiated, through access to a unique cohort of individuals, some of whom have had Coronary Artery Bypass Grafting (CABG). In the next funding cycle, tissues from subjects will be made availale for research, not only within the JHMI ADRC, but to AD investigators at collaborating institutions. This Core will also support morphological studies of transgenic and gene targeted mice engineered to study the pathogenesis and therapeutic strategies for AD. These analyses require detailed morphological studies and stereology, and this Core will provide an histology laboratory and stereology Unit for this purpose. Through these multiple activities, this Core will act to coordinate and facilitate the neuropathological evaluations of both clinical and experimental tissues relevant to AD, thereby greatly enhancing the diagnostic and research capabilities of investigators associated with the ADRC.