Factor XII-dependent thrombosis and platelet glycoprotein Ib

因子 XII 依赖性血栓形成和血小板糖蛋白 Ib

• 批准号: nhmrc : 606648
• 负责人: A/Pr Robert Andrews
• 金额: $ 22.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/factor-xii-dependent-glycoprotein-ib/94747
• 关键词: Factor; XII; dependent; thrombosis; platelet

We will determine the value of targeting the interaction between a receptor unique to platelets, glycoprotein Ib, and two factors (XI and XII) in plasma involved in blood clotting, as a novel strategy to prevent clots that lead to heart attack-stroke. Our study is at the basic research-clinical interface and has the potential to improve our understanding of both bleeding in patients with Factor XI-XII defects and prevention of dangerous levels of clotting without affecting normal vessel repair.

我们将确定靶向血小板独特受体，糖蛋白Ib和血浆中参与凝血的两种因子（XI和XII）之间相互作用的价值，作为预防导致心脏病发作-中风的血栓的新策略。我们的研究处于基础研究-临床界面，有可能提高我们对因子XI-XII缺陷患者出血和预防危险水平凝血的理解，而不影响正常血管修复。