The role of the platelet glycoprotein Ib alpha cytoplasmic domain in thrombosis

血小板糖蛋白 Ib α 胞质结构域在血栓形成中的作用

• 批准号: nhmrc : 546043
• 负责人: A/Pr Robert Andrews
• 金额: $ 40.02万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-platelet-glycoprotein-domain-thrombosis/76285
• 关键词: role; platelet; glycoprotein; Ib; alpha

Our studies aim to provide a better understanding of the factors that make platelets sticky, because this is important not only for normal blood clot formation but also in the development of harmful blood clots (thrombosis). Improving our understanding of these processes will add significantly to our knowledge of how blood clotting is controlled. This information is relevant to many human diseases including heart attack and stroke and will help us to develop drugs to prevent these diseases.

我们的研究旨在更好地了解使血小板粘性的因素，因为这不仅对正常的血凝块形成很重要，而且对有害血凝块（血栓形成）的发展也很重要。提高我们对这些过程的理解将大大增加我们对血液凝固是如何控制的知识。这些信息与许多人类疾病有关，包括心脏病发作和中风，并将帮助我们开发预防这些疾病的药物。