Platelet receptors in health and disease

健康和疾病中的血小板受体

• 批准号: nhmrc : 1004530
• 负责人: A/Pr Robert Andrews
• 金额: $ 48.53万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/platelet-receptors-health-disease/109044
• 关键词: Platelet; receptors; health; disease

The mechanisms regulating expression and function of surface receptors on blood platelets are critical for understanding cardiovascular diseases involving aberrant platelet function, not only thrombotic diseases such as heart attack or stroke, but other pathology involving platelets including coagulopathy and autoimmune thrombocytopenia caused by anti-platelet antibodies. Improved diagnosis and therapeutic targeting of platelet-specific receptors mediating arterial thrombosis can save many lives given the prevalence and severity of disease.

调节血小板表面受体表达和功能的机制对于理解涉及异常血小板功能的心血管疾病是至关重要的，不仅是血栓性疾病如心脏病发作或中风，而且是涉及血小板的其他病理学，包括由抗血小板抗体引起的凝血病和自身免疫性血小板减少症。鉴于疾病的流行和严重程度，改善血小板特异性受体介导动脉血栓形成的诊断和治疗靶点可以挽救许多生命。