Redox regulation of platelet adhesion receptors

血小板受体、糖蛋白（GP）Ib-IX-V和GPVI启动血栓形成以防止失血。不幸的是，我们对这些受体激活后立即发生的事件和已知的下游信号传导的知识存在差距。我们已经确定了一种新的结合伙伴，这些血小板受体，我们认为链接活性氧类血小板信号事件。这为预防异常凝血的治疗开辟了新的途径。

Formation of clots to prevent blood loss is initiated by the platelet receptors, glycoprotein (GP)Ib-IX-V and GPVI. Unfortunately, there is a gap in our knowledge regarding the events immediately following activation of these receptors and the known downstream signalling. We have identified a novel binding partner for these platelet receptors, which we believe links reactive oxygen species to platelet signalling events. This opens new avenues for therapies to prevent aberrant clotting.