A newly identified role for 14-3-3zeta protein in thrombosis and platelet procoagulant activity

新发现的 14-3-3zeta 蛋白在血栓形成和血小板促凝血活性中的作用

• 批准号: nhmrc : 1050817
• 负责人: A/Pr Robert Andrews
• 金额: $ 37.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/newly-identified-role-procoagulant-activity/112179
• 关键词: newly; identified; role; 14; 3zeta

Cardiovascular disease, including heart attack and stroke is the major cause of death globally, and is responsible for the death of 50,000 Australians each year. Platelet activation and blood coagulation play an important role in these diseases and we have discovered that a protein called 14-3-3 zeta is important in the processes that result in thrombosis. We are studying the mechanisms by which this protein contributes to life-threatening platelet activation with the aim of developing new and more effective anti-thrombotic drugs.

心血管疾病，包括心脏病发作和中风，是全球死亡的主要原因，每年造成5万澳大利亚人死亡。血小板活化和血液凝固在这些疾病中起着重要作用，我们已经发现一种名为14-3-3 zeta的蛋白质在导致血栓形成的过程中起着重要作用。我们正在研究这种蛋白对危及生命的血小板活化的作用机制，目的是开发新的更有效的抗血栓药物。