Mechanisms and Regulation of ACE2 Shedding

ACE2脱落的机制和调控

• 批准号: nhmrc : 436784
• 负责人: A/Pr Robert Andrews
• 金额: $ 15.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-regulation-ace2-shedding/98471
• 关键词: Mechanisms; Regulation; ACE2; Shedding

High blood pressure and heart disease, are a significant health issue affecting more than 25% of the Australian population. We have recently found that a new enzyme called ACE2 involved in cardiovascular regulation is greatly increased in heart tissue following heart attack. Furthermore, we have evidence that this enzyme is released into the blood after a heart attack or as a consequnce of chronic liver injury. The current project aims to expand on our preliminary data and to understand the basic biology underlying the mechanism of ACE2 secretion in cardiovascular and liver diseases. In addition, the measurement of ACE2 in plasma may provide useful information on prognosis and knowledge of the mechanism underlying ACE2 secretion may define new therapeutic targets to treat and prevent cardiovascular and liver disease

高血压和心脏病是影响超过 25% 澳大利亚人口的重大健康问题。我们最近发现，心脏病发作后心脏组织中一种参与心血管调节的新酶 ACE2 大大增加。此外，我们有证据表明，心脏病发作后或慢性肝损伤后，这种酶会释放到血液中。当前的项目旨在扩展我们的初步数据，并了解心血管和肝脏疾病中 ACE2 分泌机制的基础生物学。此外，血浆中 ACE2 的测量可以提供有关预后的有用信息，以及对 ACE2 分泌机制的了解可以确定治疗和预防心血管和肝脏疾病的新治疗靶点