Bio-ionic Neural Interfaces

生物离子神经接口

• 批准号: 7982472
• 负责人: Luke Satish Kumar Theogarajan
• 金额: $ 227.25万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982472
• 关键词: Address; Architecture; Area; Biocompatible; Chemical Stimulation; Chemistry; Devices; Electrical Engineering; Electronics; Extracellular Fluid; Implant; In Situ; Ions; Longevity; Medicine; Membrane; Methods; Morphologic artifacts; Neurosciences; Neurotransmitters; Physics; Polymers; Prosthesis; Risk; Stimulus; System; Work; base; density; design; nervous system disorder; neural prosthesis; potassium ion; relating to nervous system; self assembly

DESCRIPTION (Provided by the applicant) Abstract: Electronic interfaces to neural devices are fundamentally incompatible with the natural neural system. Due to the vast difference in current densities involved the electrical domain is well suited to record from neural systems but not suited for stimulation. A neural interface that provides simultaneous recording and stimulation without any stimulus artifact would truly transform the way we study, manipulate and interact with neural systems. Neurotrnsmitter based neural interfaces, are most natural but the neurotransmitter must be stored or gener- ated in-situ increasing the risk and difficulty of the interface design. This proposal outlines an electrochemical interface that circumvents these issues by using potassium ions that are sequestered from the extracellular fluid to chemically stimulate neural systems. The required concentration of ions for chemical stimulation is only 2-3X over the background concentration of 5mM. This enables the scaling of this method to the scope of the natural neural architecture which is not currently possible with electrical neural interfaces. Additionally, by building a truly biocompatible interface, some of the key issues of implant longevity can be addressed. This proposal address the challenges of building this unique electrochemical interface by integrating advances in the fields of electrical engineering, materials, chemistry and neuroscience. Potential Impact: The prime societal impact of this work is in the area of neural prosthetic devices. The design of a more efficient neural interface will enable the building of advanced devices that can alleviate some of the de- bilitating conditions that are faced by those suffering from neurological diseases. Apart from the field of medicine the concepts that are advanced by this proposal can be applied to furthering our understanding of neuroscience, organic electronics, membrane separation, understanding the physics of self-assembly and polymer synthesis. Public Health Relevance: The major goal of this project is to develop a biocompatible, high-density neural interface for neural prosthetic devices. The design of a more efficient neural interface will enable the building of advanced devices. These devices can potentially alleviate the suffering faced by patients with debilitating neurological conditions such as retinal degeneration, spinal cord injury and paralysis. Such a device can also help in further our understanding of neuroscience by allowing for simultaneous stimulation and recording from a large population of neurons.

描述（由申请人提供） 翻译后摘要：神经设备的电子接口是根本不兼容的自然神经系统。由于所涉及的电流密度的巨大差异，电域非常适合于从神经系统记录，但不适合于刺激。一个神经接口，提供同时记录和刺激，没有任何刺激伪影将真正改变我们的研究，操纵和与神经系统互动的方式。基于神经递质的神经接口是最天然的，但是神经递质必须被原位储存或产生，这增加了接口设计的风险和难度。该提案概述了一种电化学界面，该界面通过使用从细胞外液中分离的钾离子来化学刺激神经系统来规避这些问题。化学刺激所需的离子浓度仅为背景浓度5 mM的2- 3倍。这使得该方法能够扩展到自然神经架构的范围，这在电神经接口的情况下是不可能的。此外，通过构建真正的生物相容性界面，可以解决植入物寿命的一些关键问题。该提案通过整合电气工程，材料，化学和神经科学领域的进展来解决构建这种独特的电化学界面的挑战。潜在影响：这项工作的主要社会影响是在神经假体设备领域。设计一个更有效的神经接口将使先进设备的建设，可以减轻一些衰弱的条件，所面临的那些患有神经系统疾病。除了医学领域之外，这项建议所提出的概念还可以应用于促进我们对神经科学，有机电子学，膜分离，自组装和聚合物合成物理学的理解。 公共卫生相关性：该项目的主要目标是为神经假体设备开发生物相容性，高密度神经接口。设计更有效的神经接口将使先进设备的建造成为可能。这些设备可以潜在地减轻患有视网膜变性、脊髓损伤和瘫痪等神经系统疾病的患者所面临的痛苦。这样的设备还可以通过允许同时刺激和记录大量神经元来帮助我们进一步理解神经科学。

项目成果

Rapid Metal -free Macromolecular Coupling via in situ Nitrile Oxide-Activated Alkene Cycloaddition.

• DOI: 10.1002/pola.27371
• 发表时间: 2014-11-01
• 期刊: Journal of polymer science. Part A, Polymer chemistry
• 作者: Isaacman MJ;Cui W;Theogarajan LS
• 通讯作者: Theogarajan LS

Integration of solid-state nanopores in a 0.5 μm CMOS foundry process.

在0.5μmCMOS铸造过程中固态纳米孔的整合。

• DOI: 10.1088/0957-4484/24/15/155501
• 发表时间: 2013-04-19
• 期刊: Nanotechnology
• 影响因子: 3.5
• 作者: Uddin A;Yemenicioglu S;Chen CH;Corigliano E;Milaninia K;Theogarajan L
• 通讯作者: Theogarajan L

Wafer Scale Integration of CMOS Chips for Biomedical Applications via Self-Aligned Masking.

• DOI: 10.1109/tcpmt.2011.2166395
• 发表时间: 2011-12-01
• 期刊: IEEE transactions on components, packaging, and manufacturing technology
• 作者: Uddin A;Milaninia K;Chen CH;Theogarajan L
• 通讯作者: Theogarajan L

Stealth polymeric vesicles via metal-free click coupling.

• DOI: 10.1021/bm400940h
• 发表时间: 2013-09-09
• 期刊: BIOMACROMOLECULES
• 影响因子: 6.2
• 作者: Isaacman, Michael J.;Corigliano, Eleonora M.;Theogarajan, Luke S.
• 通讯作者: Theogarajan, Luke S.

Solid-state nanopore based biomimetic voltage gated ion channels.

基于固态纳米孔的仿生电压门控离子通道。

• DOI: 10.1088/1748-3190/aa811b
• 发表时间: 2017
• 期刊: Bioinspiration & biomimetics
• 影响因子: 3.4
• 作者: Pevarnik,Matthew;Cui,Weibin;Yemenicioglu,Sukru;Rofeh,Justin;Theogarajan,Luke
• 通讯作者: Theogarajan,Luke