Frontal asymmetries and interpersonal anger, aggression, and inhibition across ad

广告中的额叶不对称和人际愤怒、攻击性和抑制

• 批准号: 7912131
• 负责人: Jill Malik
• 金额: $ 2.84万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-23 至 2012-11-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7912131
• 关键词: Aggressive behavior; Anger; Behavioral; Behavioral inhibition; Emotional; Emotions; Goals; Lead; Left; Life; Longevity; Mediating; Pathway interactions; Pattern; Prefrontal Cortex; Prevention; Research; Research Design; Right-On; Role; Withdrawal; arm; neuromechanism; pre-doctoral; programs; public health relevance

DESCRIPTION (provided by applicant): There is growing evidence that left versus right prefrontal activation asymmetries support approach- and withdrawal-related emotions, respectively. Anger is associated with aggressive behavior and reduced inhibition, which has been shown to rely on the right prefrontal cortex. This proposal aims to explore the role of approach-related prefrontal activity in mediating the relationship between anger and behavioral inhibition. This will be accomplished by examining deficits in behavioral inhibition following anger induction as well as activity on a behavioral aggression task, as a function of both baseline and anger-induced asymmetries in prefrontal cortex activity. Lastly, lifespan considerations will be explored in respect to the mechanisms leading from anger to aggression, as research suggests a differential pattern of emotional responding later in life. This is a predoctoral proposal that will be the first step in a program of research designed to understand the neural mechanisms that lead from anger to aggression; the ultimate goal is to predict and mitigate anger-related changes in aggressive behavior. PUBLIC HEALTH RELEVANCE: This proposal seeks to explore the underlying, neural mechanisms that are associated with the pathway leading from anger to aggression. Armed with this information, it is hoped that this line of research will be able to inform prevention and treatment for anger and aggression.

描述（由申请人提供）：越来越多的证据表明，左右前额叶激活不对称分别支持接近和退缩相关的情绪。愤怒与攻击性行为和抑制能力下降有关，而这依赖于右侧前额叶皮层。本研究旨在探讨方法相关的前额叶活动在愤怒和行为抑制之间的中介作用。这将通过检查愤怒诱导后的行为抑制缺陷以及行为攻击任务的活动来完成，作为基线和愤怒诱导的前额皮质活动不对称的功能。最后，我们将探讨从愤怒到攻击的机制，因为研究表明，在生命的后期，情绪反应会有不同的模式。这是一个博士前的提案，将是一个研究项目的第一步，该项目旨在了解从愤怒到攻击的神经机制；最终目标是预测和减轻攻击性行为中与愤怒相关的变化。