Sjogren's: Transition from Autoimmunity to Lymphoma

描述（由申请人提供）：“Sjogrens：从自身免疫到淋巴瘤的转变”是Sjogrens综合征基金会的基础科学研讨会，计划于2005年9月23日至25日举行，旨在促进科学数据的交流，并催化关于从自身免疫到淋巴瘤转变的潜在触发因素的严格讨论。研讨会将引入来自不同相关领域的演讲者，包括免疫学、自身免疫和肿瘤学的研究人员，他们中的许多人以前没有关注过干燥综合征，从而产生新鲜和新颖的概念。干燥综合征是最常见的自身免疫性疾病之一，约有5-10%的干燥综合征患者会发展为淋巴瘤，特别是非霍奇金b细胞淋巴瘤，其组织病理学类型为MALT，或粘膜相关淋巴瘤。对当前治疗方法的临床概述以及对干燥病和淋巴瘤之间密切联系的认识，将为围绕这一联系的基础科学问题的后续讨论奠定基础。与会的研究人员将介绍他们在以下新兴领域对干燥淋巴瘤的出现和治疗的潜在作用的最新发现：b细胞和t细胞机制；b淋巴细胞刺激剂（BLyS）；遗传学;细胞程序性死亡；信号通路;runt域家族转录因子；免疫反应和细胞增殖控制的中断或检查点，淋巴增生可能转变为恶性肿瘤；以及新方向、未来研究计划、合作领域和注册的定义。为了激励年轻的研究者从事与淋巴瘤-自身免疫过渡相关的基础研究，每位演讲者将被邀请从他们的实验室中选择一名特别有才华的研究者参加研讨会讨论，并在特别会议期间展示海报。

DESCRIPTION (provided by applicant): "Sjogrens:Transitions from Autoimmunity to Lymphoma" is a Sjogrens Syndrome Foundation basic scientific workshop scheduled for Sept. 23-25, 2005 and is designed to foster the exchange of scientific data and catalyze rigorous discussion about potential triggers in the transition from autoimmunity to lymphoma. The workshop will generate fresh and novel concepts by bringing in speakers from a variety of related fields, including researchers in immunology, autoimmunity, and oncology - many of whom have not previously focused on Sjogren's syndrome. About 5-10% of those with Sjogren's syndrome, one of the most common autoimmune disorders, develop lymphoma, specifically non-Hodgkin's B-cell lymphoma enriched for the histopathologic type classified as MALT, or mucosa-associated lymphoma. A clinical overview of the current treatment and knowledge about the close link between Sjogren's and lymphoma will set the stage for subsequent discussions about basic scientific questions surrounding that link. Participating investigators will present their most recent discoveries in the potential role of the following burgeoning areas on the emergence and treatment of lymphoma in Sjogren's: B-cell and T-cell mechanisms; B-Lymphocyte Stimulator (BLyS); genetics; programmed cell death; signaling pathways; transcription factors of the Runt-domain family; breaks or checkpoints in the control of immune response and cell proliferation in which lymphoproliferation might transform into a malignancy; and definition of new directions, future research initiatives, areas for collaboration, and registries. To inspire young investigators to undertake basic research related to the lymphoma-autoimmune transition, each speaker will be invited to select a particularly talented investigator from their laboratory to attend and participate in workshop discussions and present posters during a special session.