Sjogren's: Transition from Autoimmunity to Lymphoma

干燥症：从自身免疫到淋巴瘤的转变

• 批准号: 6941014
• 负责人: ELAINE ALEXANDER
• 金额: $ 4.9万
• 依托单位: SJOGREN'S SYNDROME FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-23 至 2006-06-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941014
• 关键词: Sjogren' s syndrome; apoptosis; autoimmunity; biological signal transduction; immune response; leukocyte activation /transformation; lymphoma; meeting /conference /symposium; pathologic process; travel; workshop

DESCRIPTION (provided by applicant): "Sjogrens:Transitions from Autoimmunity to Lymphoma" is a Sjogrens Syndrome Foundation basic scientific workshop scheduled for Sept. 23-25, 2005 and is designed to foster the exchange of scientific data and catalyze rigorous discussion about potential triggers in the transition from autoimmunity to lymphoma. The workshop will generate fresh and novel concepts by bringing in speakers from a variety of related fields, including researchers in immunology, autoimmunity, and oncology - many of whom have not previously focused on Sjogren's syndrome. About 5-10% of those with Sjogren's syndrome, one of the most common autoimmune disorders, develop lymphoma, specifically non-Hodgkin's B-cell lymphoma enriched for the histopathologic type classified as MALT, or mucosa-associated lymphoma. A clinical overview of the current treatment and knowledge about the close link between Sjogren's and lymphoma will set the stage for subsequent discussions about basic scientific questions surrounding that link. Participating investigators will present their most recent discoveries in the potential role of the following burgeoning areas on the emergence and treatment of lymphoma in Sjogren's: B-cell and T-cell mechanisms; B-Lymphocyte Stimulator (BLyS); genetics; programmed cell death; signaling pathways; transcription factors of the Runt-domain family; breaks or checkpoints in the control of immune response and cell proliferation in which lymphoproliferation might transform into a malignancy; and definition of new directions, future research initiatives, areas for collaboration, and registries. To inspire young investigators to undertake basic research related to the lymphoma-autoimmune transition, each speaker will be invited to select a particularly talented investigator from their laboratory to attend and participate in workshop discussions and present posters during a special session.

描述（由申请人提供）：“干燥：从自身免疫到淋巴瘤的转变”是干燥综合征基金会定于9月9日举行的基础科学研讨会。23-25，2005年，旨在促进科学数据的交流，并催化关于从自身免疫向淋巴瘤转变的潜在触发因素的严格讨论。该研讨会将通过引入来自各种相关领域的演讲者来产生新鲜和新颖的概念，包括免疫学，自身免疫和肿瘤学的研究人员-其中许多人以前没有关注过干燥综合征。约5-10%的患有干燥综合征（最常见的自身免疫性疾病之一）的患者发展为淋巴瘤，特别是非霍奇金B细胞淋巴瘤，其富集了归类为MALT的组织病理学类型，或粘膜相关淋巴瘤。目前治疗的临床概述和关于干燥综合征和淋巴瘤之间密切联系的知识将为随后围绕该联系的基本科学问题的讨论奠定基础。参与的研究人员将介绍他们在以下新兴领域对干燥综合征淋巴瘤的出现和治疗的潜在作用方面的最新发现：B细胞和T细胞机制; B淋巴细胞刺激因子（BLyS）;遗传学;程序性细胞死亡;信号通路; Runt结构域家族的转录因子;免疫反应和细胞增殖控制中的中断或检查点，其中淋巴细胞增殖可能转化为恶性肿瘤;以及新方向、未来研究计划、合作领域和注册的定义。为了激励年轻的研究人员进行与淋巴瘤-自身免疫性转变相关的基础研究，每位演讲者将被邀请从他们的实验室中选择一位特别有才华的研究人员出席并参加研讨会讨论，并在特别会议期间展示海报。