Struc Analysis of Supramolec Assemblies by Hybrid Method

描述(由申请人提供)：该项目的目标是召开一个为期四天的研讨会，主题是“用杂交方法进行超分子组装的结构分析”，汇集结构生物学不同分支的专家，主要来自X射线结晶学、电子冷冻显微镜和计算生物学领域。议程还将延伸到生物物理方法、蛋白质组学和细胞生物学。这次讲习班是在2004年3月和1998年4月就同一主题成功举行了两次会议之后举行的。它的目标是通过说明混合方法的力量来解决具有挑战性的大型系统，并通过确定当前实践的混合方法中的限制和差距，来调查这一令人兴奋的研究领域的最新技术。研讨会的基础是以下新兴概念：(1)大分子组件和机器代表大多数基本过程的结构层次中的关键层次；(2)通过适当的实验方法组合，即“混合方法”，可以最有效地研究这些实体。研讨会将于2006年3月15日至19日在加利福尼亚州太浩湖的Granlibakken会议上举行。它的计划将包括2个主题演讲，7个平台会议，包括邀请演讲(70%)和从提交的摘要中挑选演讲(30%)，以及2个海报会议。平台会议的专题如下：大分子细丝的混合方法；膜复合体的混合方法；混合分析的计算方法；动态组装的混合方法；动力学大分子组装和机器的混合方法；大分子机器的混合方法；以及细胞蛋白质组学。组委会由Dorit Hanein博士和John Tainer博士担任会议主席，Janet Thornton、Alasdair Steven和Karl-Peter Hopfner博士担任组委会成员。讲习班将进行广泛宣传，并将在组织者所能达到的范围内尽可能具有包容性和对多样性有敏感认识，并将允许150人参加。

DESCRIPTION (provided by applicant): The goal of this project is to convene a four-day Workshop on the cutting-edge topic of "Structural Analysis of Supramolecular Assemblies by Hybrid Methods," bringing together specialists in diverse branches of structural biology, drawing primarily from the fields of x-ray crystallography, electron cryomicroscopy, and computational biology. The agenda will also extend to biophysical methods, proteomics and cell biology. This Workshop follows two successful meetings on the same theme in March 2004 and April 1998. Its goal is to survey the state of the art in this exciting area of research by illustrating the power of hybrid methods to tackle challenging megasystems and by identifying limitations and gaps in hybrid methods as currently practiced. The Workshop is based on the emerging concepts that (1) macromolecular assemblies and machines represent the pivotal level in the structural hierarchy for most fundamental processes; and (2) these entities may be most effectively studied by appropriate combinations of experimental methods, i.e. "hybrid approaches." The Workshop will be held from the 15th-19th March 2006 at the Granlibakken Conference in Lake Tahoe, CA. Its program will consist of 2 keynote lectures, 7 platform sessions with both invited talks (70%) and talks selected from submitted abstracts (30%), and 2 poster sessions. The platform session topics are as follows: Hybrid Approaches to Macromolecular Filaments; Hybrid Approaches to Membrane Complexes; Computational Approaches to Hybrid Analysis; Hybrid Approaches to Dynamic Assemblies; Hybrid Approaches to Dynamics Macromolecular Assemblies and Machines; Hybrid Approaches to Macromolecular Machines; and Cellular Proteomics. The organizing committee consists of Drs. Dorit Hanein and John Tainer acting as Chairs of the meeting and Drs. Janet Thornton, Alasdair Steven and Karl-Peter Hopfner acting as members of the organizing committee. The Workshop will be extensively advertised and will be as inclusive and diversity-sensitive as the organizers can achieve and the 150-participant limit will allow.