Core A: ADMINISTRATIVE

核心A：行政

• 批准号: 8234231
• 负责人: DORIT HANEIN
• 金额: $ 50.52万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234231
• 关键词: Accounting; Actins; Adhesions; Administrative Personnel; Administrator; Back; Bacteria; Budgets; Cell physiology; Cells; Cellular biology; Collaborations; Communication; Computer software; Computers; Consult; Consultations; Cytoskeleton; Data; Documentation; Electronic Mail; Emerging Technologies; Engineering; Ensure; Ethers; Faculty; Feedback; Fostering; Freezing; Funding; Future; Goals; Grant; High Performance Computing; Human Resources; Image; Individual; Institution; International; Interruption; Joints; Journals; Laboratories; Leadership; Learning; Letters; Light; Link; Maintenance; Mechanics; Methodology; Molecular; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; Peer Review; Polymers; Postdoctoral Fellow; Preparation; Printing; Process; Productivity; Progress Reports; Publications; Published Comment; Reagent; Reporting; Research; Research Personnel; Resolution; Resources; Right-On; Role; Sampling; Schedule; Science; Scientific Advances and Accomplishments; Scientist; Security; Signal Transduction; Singapore; Site; Specimen; Structure; Students; Supervision; Technology; Teleconferences; Telephone; Time; Training; Travel; Tubulin; Universities; Update; Visit; Work; Workload; Writing; base; biochemical model; cell motility; cost; experience; graduate student; instrument; interest; light microscopy; meetings; member; novel; physical model; planetary Atmosphere; programs; skills; stem cell differentiation; symposium; web page; web site

B. ADMINISTRATIVE TASKS In addition to routine administrative tasks such as interaction with institutional administrators and the grant accounting personnel, dissemination of printed material, copying, typing, handling correspondence, etc, Core A will be responsible for organizing the following scientific venues and mechanisms, 1. Steering Committee. Drs, Hanein, Danuser, Horwitz, Schwartz, Ginsberg and Volkmann will form the Steering Committee for this Program Project, The steering committee will held 10-15 minutes monthly conference calls, which will be the forum for discussion of all major issues regarding the PPG as well as discussion of the month-to-month scientific progress and future planning. The discussions will include new strategies or directions for the Program Project, emerging technologies, or the impact of major breakthroughs in the field. The Pl will plan and chair these meetings. In fact, these phone meetings as well as exchange of documents via DropboxTM have already been established as the communication instruments for the preparation of this application 2. Scientific Advisory Board (SAB). The Program Project will be supported by the SAB, which will consist of four prominent scientists and leaders in the fields of cell migration, force sensing, high resolution light and/or EM imaging. All SAB members accepted our invitation (see letters). Dr. Kenneth Downing (LBNL at UC Berkeley). His research focuses on the structure and function of tubulin, actin-micretubules interactions, and developing frozen-hydrated specimen preparation methodology for imaging cytoskeleton of small bacteria. Dr. Dennis E. Discher (UPenn). His lab is broadly interested in cell mechanics and polymer engineering, studying among others the underlying principles of controlling stem cell differentiation with novel materials and polymers. Dr. Michael Sheetz (Columbia University and National University of Singapore). An expert in force depending signaling and in quantitative physical and biochemical models determining dynamic cellular function. Dr. Clare M Waterman (NHLBI). Her current research integrates high resolution light microscopy with molecular cell biology to study directed cell migration (qFSM and IPALM). The main function of the SAB is to provide critical feedback en the goals and progress of the research planned and accomplished in the Program Project. The SAB members will attend the Annual Retreat, which will allow them to evaluate the overall progress of the Program Project. Comments will be provided to the PI via teleconference and email correspondence. Members of the SAB will also be consulted by phone from time to time to assist in major decisions concerning the course of the work, and new opportunities, 3. Training and interactions. A critically important level of interaction will be inter-lab visits by graduate students and postdoctoral fellows. These visits have already been initiated and several students/postdoctoral fellows (Danuser's, Horwitz's labs) have visited the Hanein lab to learn the basics of the LM/EM sample preparations. Funds have been requested to facilitate these visits, and past experience demonstrates that these exchanges are extremely productive. The core will also encourage trainees to participate actively in the scientific presentations and discussions. Scientific presentations of data in joint meetings will be primarily done by graduate students and postdocs, with only brief overviews by faculty. The annual retreat (see below) will be another excellent opportunity to deepen the interactions. 4. PPG Administrator. The Program benefits from the expertise of an outstanding administrative assistant, Ms. Debbie Signer. Ms. Signer has excellent organizational skills and has the ability to prioritize workload, meet deadlines, and work with frequent interruptions, and is proficient with the MSOffice Suite and EndNote, on both Macintosh and PC computers. The administrative assistant is provided by SBIMR and will act as PPG administrator and assist Dr. Hanein in all duties outlined above. In her role as Program Project Administrator, Debbie will coordinate the scheduling of the annual retreat and face-to-face meetings of the project leaders, scheduling of video conference call meetings, quarterly and annual reviews to NIGMS, documentation of reviews, dissemination of meeting schedules, budgets, management and the accounting of cere resources. The administrator will facilitate efficient interfacing of the investigators at the various institutions and their grants managements, ether administrative personnel. 5. Monthly video conference call meetings. The seven laboratories (Hanein, Volkmann, Danuser, Horwitz, Ginsberg, Schwartz and Groisman) will have a joint monthly video conference call meetings (the Steering Committee conference calls will precede these meetings), which will include students and post-doctoral fellows presenting their work pertaining to the PPG for discussion. Each meeting will have a short presentation of updates by two of the projects, followed by general discussion, 15 minutes at the end are reserved for trouble-shooting questions, ensuring that reagents, software and technologies shared between the labs are appropriately used. These meetings will be attended by all members of the all laboratories (approximately 25 people). 6. Annual Retreat. An annual review of the Projects and Ceres will be performed at least one month in advance of the non-competing progress report deadline. This review will be carried out in the form of an Annual Retreat attended by all Pis, lab members of the on-site labs, one or two key lab members of the off-site labs, and the SAB members. These retreats will be held at SBIMR in La Jolla, which will limit travel to 50% of the team and thus minimize costs. The Annual Retreat will consist of a full day of presentations by the project leaders, graduate students and pest-doctoral fellows from each laboratory. This retreat will not only assist the investigators in obtaining objective views of their scientific progress and advice to overcome potential obstacles, but will also provide an additional avenue for integrating input of pre- and pest-doctoral fellows. 7. Annual progress report. The Annual Retreat will be the basis for a written annual progress report, in addition to Dr. Hanein's summary and each investigator¿s report. This report will be sent to NIGMS as part of the non-competing renewal process. 8. Scientific publications and Program Project homepage. The principal avenue for public dissemination of the scientific results obtained in the context of this Program Project will be publications in peer-reviewed international journals. The overall objective of the Program Project is to provide important scientific advances and breakthroughs. The Program Project webpage will outline the scientific goals of Program Project, lists and summaries of publications, and available reagents. For software dissemination, links will be maintained to the downlead websites of the Danuser and Volkmann labs. The web page will also link to all the investigator¿s websites and their publications. The website will be created with help of the resources available at the SBMRI for the creation and maintenance of scientific websites. Towards this goal. Dr. Hanein will be directly assisted by the High Performance Computing (HPC) team (Dr. C. Weber and Mr. L. Kasko) she currently supervises. The format and security of the website will also be maintained with the help and expertise at HPC/SBMRI.

B. 行政任务 除了与机构管理人员和拨款会计人员互动、分发印刷材料、复印、打字、处理信件等日常行政任务外，核心 A 将负责组织以下科学场所和机制： 1. 指导委员会。 Hanein、Danuser、Horwitz、Schwartz、Ginsberg 和 Volkmann 博士将组成该计划项目的指导委员会，指导委员会每月举行 10-15 分钟会议 电话会议，这将是讨论有关 PPG 的所有重大问题以及讨论逐月科学进展和未来规划的论坛。讨论将包括该计划项目的新战略或方向、新兴技术或该领域重大突破的影响。 PL 将计划并主持这些会议。事实上，这些电话会议以及通过 DropboxTM 交换文件已经成为准备本申请的沟通工具。 2. 科学顾问委员会 (SAB)。该计划项目将得到 SAB 的支持，该委员会将由细胞迁移、力传感、高分辨率光和/或电磁成像领域的四位杰出科学家和领导者组成。所有 SAB 成员都接受了我们的邀请（见信件）。 肯尼斯·唐宁博士（加州大学伯克利分校劳伦斯伯克利国家实验室）。他的研究重点是微管蛋白的结构和功能、肌动蛋白-微管相互作用以及开发冷冻水合标本制备 小细菌细胞骨架成像方法。 丹尼斯·E·迪舍尔博士（宾夕法尼亚大学）。他的实验室对细胞力学和聚合物广泛感兴趣 工程，研究利用新型材料和聚合物控制干细胞分化的基本原理。 Michael Sheetz 博士（哥伦比亚大学和新加坡国立大学）。力依赖信号传导以及确定动态细胞功能的定量物理和生化模型方面的专家。 克莱尔·M·沃特曼 (Clare M Waterman) 博士 (NHLBI)。她目前的研究将高分辨率光学显微镜与分子细胞生物学相结合，以研究定向细胞迁移（qFSM 和 IPALM）。 SAB 的主要职能是就计划项目中计划和完成的研究的目标和进展提供关键反馈。 SAB 成员将参加年度静修会，以便他们评估计划项目的整体进展。意见将通过电话会议和电子邮件通信的方式提供给 PI。 SAB 成员还将不时接受电话咨询，以协助做出有关工作进程和新机会的重大决策， 3. 培训和互动。研究生和博士后研究员的实验室间访问将是一个至关重要的互动层面。这些访问已经开始，一些学生/博士后研究员（Danuser 的、Horwitz 的实验室）已经访问了 Hanein 实验室，以了解 LM/EM 样品制备的基础知识。已要求提供资金来促进这些访问，过去的经验表明，这些交流非常富有成效。核心还将鼓励学员积极参与科学演示和讨论。联席会议上对数据的科学陈述将主要由研究生和博士后完成，仅进行简短的介绍 教师的概述。年度务虚会（见下文）将是加深互动的另一个绝佳机会。 4. PPG 管理员。该计划受益于杰出行政助理 Debbie Signer 女士的专业知识。 Signer 女士具有出色的组织能力，能够确定工作量的优先顺序、按时完成工作、在经常中断的情况下工作，并且精通 Macintosh 和 PC 计算机上的 MSOffice Suite 和 EndNote。行政助理是 由 SBIMR 提供，并将担任 PPG 管理员并协助 Hanein 博士履行上述所有职责。 作为计划项目管理员，黛比将协调项目负责人的年度务虚会和面对面会议的安排、视频电话会议的安排、NIGMS 的季度和年度审查、审查记录、会议时间表的分发、预算、管理和 Cere 资源的会计。管理员将促进各个机构的调查人员与其资助管理人员、以太行政人员之间的有效联系。 5.每月召开视频电话会议。七个实验室（Hanein、Volkmann、Danuser、Horwitz、Ginsberg、Schwartz 和 Groisman）每月将举行一次联合视频电话会议（指导委员会电话会议将在这些会议之前进行），学生和博士后研究员将介绍他们与 PPG 相关的工作以供讨论。每次会议都会有两个项目的简短介绍，然后进行一般性讨论，最后留出 15 分钟用于解决问题，确保实验室之间共享的试剂、软件和技术得到适当使用。所有实验室的所有成员（约 25 人）将出席这些会议。 6. 年度静修。对项目和 Ceres 的年度审查将在非竞争性进度报告截止日期之前至少一个月进行。该审查将以年度静修的形式进行，所有 Pis、现场实验室的实验室成员、场外实验室的一到两名关键实验室成员以及 SAB 成员都将参加。这些静修活动将在拉霍亚的 SBIMR 举行，这将限制团队 50% 的人员出差，从而最大限度地降低成本。年度静修活动将包括来自每个实验室的项目负责人、研究生和害虫博士研究员的一整天的演讲。 这次务虚会不仅有助于研究人员获得对其科学进展的客观看法和克服潜在障碍的建议，而且还将为整合博士前研究员和害虫博士研究员的投入提供额外的途径。 7. 年度进度报告。除了 Hanein 博士的总结和每位研究者的报告之外，年度静修将成为书面年度进展报告的基础。该报告将作为非竞争性更新流程的一部分发送给 NIGMS。 8. 科学出版物和计划项目主页。公众的主要途径 传播本计划项目中获得的科学成果将在同行评审的国际期刊上发表。该计划项目的总体目标是提供重要的科学进展和突破。计划项目网页将概述计划项目的科学目标、出版物的列表和摘要以及可用的试剂。对于软件传播，将保留 Danuser 和 Volkmann 实验室的下载网站的链接。该网页还将链接到所有调查人员的网站及其出版物。该网站将借助 SBMRI 的可用资源来创建，用于创建和维护科学网站。朝着这个目标。 Hanein 博士将得到她目前领导的高性能计算 (HPC) 团队（C. Weber 博士和 L. Kasko 先生）的直接协助。网站的格式和安全性也将在 HPC/SBMRI 的帮助和专业知识下得到维护。