International Conference on Image Analysis in Three-dimensional Cryo-EM

描述（由申请人提供）：本申请的目标是召开为期三天的研讨会，主题为“三维冷冻电子显微镜中的图像分析”，定于2015年早春举行。这将遵循第一次研讨会，将于2014年3月12日至15日在太浩湖的Granlibakken会议中心举行，加利福尼亚州。该研讨会的目标是汇集算法开发专家，以评估解决具有挑战性的生物学问题的图像分析方法的最新技术水平，并讨论目前在3D cryo-EM领域的局限性和障碍。该研讨会将为该领域的开发人员提供一个开放的论坛，既包括已建立的开发人员，也包括学生/博士后，以考虑这个快速发展领域的详细算法和方法，并确定最需要共同努力的领域。该研讨会的中心前提是，获得高度复杂的生物机器，复合体和细胞器的全面和定量的了解需要积极，及时和协调的互补图像分析和数据挖掘算法和方法的发展。该计划包括一个主题演讲，五个平台会议，邀请演讲（70%），从提交的摘要中选择的演讲（30%），以及两个海报会议。所有会议将侧重于互动讨论，有足够的时间提问。2014年的会议将包括一个特别的“愿景”谈“过去和未来的图像分析方法”的大卫DeRosier，布兰迪斯大学。会谈将调查新方法的发展努力，结合更“传统”的成像方法的进展细节。2014年会议的当前平台会议是：地图验证;螺旋对称和2-D晶体的单粒子方法;直接探测器电影处理;断层图像分割，注释和过滤;限制单粒子分析/断层扫描分辨率的因素; 2-D和3-D中的异质数据。D博士Hanein和S. Ludtke担任会议主席，W. Chiu（US），E. Egelman（US），B. Hankamer（澳大利亚），M. Kikkawa（日本），D. Mastronarde（US），P. Penczek（US），H.斯塔尔贝格（欧洲），F. Sun（中国）和N.美国人是组委会的成员。讲习班将广泛宣传，并将尽组织者所能做到的包容性和多样性敏感性，100名与会者的限制也将允许。

DESCRIPTION (provided by applicant): The goal of this application is to convene a three-day Workshop on the cutting-edge topic of "Image Analysis in Three-Dimensional Cryo-Electron Microscopy" slated for early spring 2015. This would follow the 1st workshop, which will be held from March 12-15, 2014 at the Granlibakken Conference Center at Lake Tahoe, CA. The goal of the workshop is to bring together specialists in algorithm development to assess the state of the art in image analysis approaches that tackle challenging biological problems and to discuss current limitations and road blocks in the 3D cryo-EM field as currently practiced. The workshop will provide an open forum for developers in this area, both established as well as students/postdocs to consider the detailed algorithms and methodologies in this fast developing field and identify areas in the most need of concerted effort. The central premise of the workshop is that gaining a comprehensive and quantitative understanding of highly sophisticated biological machines, complexes, and organelles of the cell requires the active, timely and coordinated development of complementary image analysis and data mining algorithms and approaches. The program consists of one keynote lecture, five platform sessions with both invited talks (70%), and talks selected from submitted abstracts (30%), as well as two poster sessions. All sessions will focus on interactive discussions with plenty of time for questions. The 2014 meeting will include a special "Vision" talk on the "Past and future of image analysis methods" by David DeRosier, Brandeis University. The talks will survey new method development efforts combined with details on advances within more "traditional" imaging approaches. The current platform sessions for the 2014 meeting are: Map Validation; Single Particle Approaches to Helical Symmetry and 2-D Crystals; Direct Detector Movie Processing; Tomogram Segmentation, Annotation and Filtration; Factors Limiting Resolution in Single Particle Analysis/Tomography; Heterogeneous Data in 2-D and 3-D. Drs. D. Hanein and S. Ludtke serve as Chairs of the meeting and Drs. W. Chiu (US), E. Egelman (US), B. Hankamer (Australia), M. Kikkawa (Japan), D. Mastronarde (US), P. Penczek (US), H. Stahlberg (Europe), F. Sun (China), and N. Volkmann (US) are members of the organizing committee. The Workshop will be extensively advertised and will be as inclusive and diversity-sensitive as the organizers can achieve and the 100-participant limit will allow.