International Conference on Image Analysis in Three-dimensional Cryo-EM

描述(申请人提供)：该申请的目标是召开一个为期三天的研讨会，主题是“图像分析在三维低温电子显微镜”的前沿主题，定于2015年初春。在此之前，第一次研讨会将于2014年3月12日至15日在加利福尼亚州太浩湖的格兰利巴肯会议中心举行。研讨会的目标是将算法开发方面的专家聚集在一起，评估解决具有挑战性的生物学问题的图像分析方法的最新水平，并讨论目前在3D冷冻-EM领域的当前限制和障碍。研讨会将为这一领域的开发人员以及学生/博士后提供一个开放的论坛，以考虑这一快速发展领域的详细算法和方法，并确定最需要共同努力的领域。研讨会的中心前提是，要全面和定量地了解高度复杂的生物机器、复合体和细胞细胞器，需要积极、及时和协调地开发互补的图像分析和数据挖掘算法和方法。该计划包括一次主题演讲，五次平台会议，两次受邀演讲(70%)，从提交的摘要中挑选演讲(30%)，以及两次海报会议。所有会议将集中于互动讨论，并有充足的时间提问。2014年的会议将包括由布兰迪斯大学的David DeRosier作的关于“图像分析方法的过去和未来”的特别“愿景”演讲。讲座将回顾新方法的开发工作，并详细介绍更“传统”成像方法的进展情况。2014年会议目前的平台会议是：地图验证；单粒子螺旋对称和2-D晶体方法；直接探测器电影处理；断层图像分割、注释和过滤；单粒子分析/断层成像中限制分辨率的因素；2-D和3-D中的非均匀数据。D.Hanein博士和S.Ludtke博士担任会议主席，W.Chiu博士(美国)、E.Egelman博士(美国)、B.Hankamer博士(澳大利亚)、M.Kikkawa博士(日本)、D.Mastronarde博士(美国)、P.Penczek博士(美国)、H.Stahlberg博士(欧洲)、F.Sun博士(中国)和N.Volkmann博士(美国)担任组委会成员。讲习班将进行广泛宣传，并将在组织者所能达到的范围内尽可能具有包容性和对多样性有敏感认识，并将允许参加100人的限制。

DESCRIPTION (provided by applicant): The goal of this application is to convene a three-day Workshop on the cutting-edge topic of "Image Analysis in Three-Dimensional Cryo-Electron Microscopy" slated for early spring 2015. This would follow the 1st workshop, which will be held from March 12-15, 2014 at the Granlibakken Conference Center at Lake Tahoe, CA. The goal of the workshop is to bring together specialists in algorithm development to assess the state of the art in image analysis approaches that tackle challenging biological problems and to discuss current limitations and road blocks in the 3D cryo-EM field as currently practiced. The workshop will provide an open forum for developers in this area, both established as well as students/postdocs to consider the detailed algorithms and methodologies in this fast developing field and identify areas in the most need of concerted effort. The central premise of the workshop is that gaining a comprehensive and quantitative understanding of highly sophisticated biological machines, complexes, and organelles of the cell requires the active, timely and coordinated development of complementary image analysis and data mining algorithms and approaches. The program consists of one keynote lecture, five platform sessions with both invited talks (70%), and talks selected from submitted abstracts (30%), as well as two poster sessions. All sessions will focus on interactive discussions with plenty of time for questions. The 2014 meeting will include a special "Vision" talk on the "Past and future of image analysis methods" by David DeRosier, Brandeis University. The talks will survey new method development efforts combined with details on advances within more "traditional" imaging approaches. The current platform sessions for the 2014 meeting are: Map Validation; Single Particle Approaches to Helical Symmetry and 2-D Crystals; Direct Detector Movie Processing; Tomogram Segmentation, Annotation and Filtration; Factors Limiting Resolution in Single Particle Analysis/Tomography; Heterogeneous Data in 2-D and 3-D. Drs. D. Hanein and S. Ludtke serve as Chairs of the meeting and Drs. W. Chiu (US), E. Egelman (US), B. Hankamer (Australia), M. Kikkawa (Japan), D. Mastronarde (US), P. Penczek (US), H. Stahlberg (Europe), F. Sun (China), and N. Volkmann (US) are members of the organizing committee. The Workshop will be extensively advertised and will be as inclusive and diversity-sensitive as the organizers can achieve and the 100-participant limit will allow.