International Conference on Image Analysis in Three-dimensional Cryo-EM

描述（由申请人提供）：本申请的目标是在2015年早春召开为期三天的关于“三维冷冻电子显微镜图像分析”的前沿主题的研讨会。第一次研讨会将于2014年3月12日至15日在加利福尼亚州太浩湖的格兰利巴肯会议中心举行。研讨会的目标是汇集算法开发方面的专家，以评估解决具有挑战性的生物问题的图像分析方法的最新状态，并讨论目前3D冷冻电镜领域的局限性和障碍。研讨会将为该领域的开发人员提供一个开放的论坛，包括已建立的以及学生/博士后，以考虑这个快速发展领域的详细算法和方法，并确定最需要协同努力的领域。研讨会的中心前提是，对高度复杂的生物机器、复合物和细胞细胞器进行全面和定量的了解，需要积极、及时和协调地发展互补的图像分析和数据挖掘算法和方法。该计划包括一个主题演讲，五个平台会议，其中邀请演讲（70%）和从提交的摘要中选择的演讲（30%），以及两个海报会议。所有的会议都将以互动讨论为重点，并有充足的提问时间。2014年的会议将包括布兰代斯大学的David DeRosier关于“图像分析方法的过去和未来”的特别“愿景”演讲。会谈将调查新方法的开发工作，并结合更“传统”成像方法的进展细节。2014年会议目前的平台会议有：地图验证；螺旋对称和二维晶体的单粒子研究直接检测器电影处理；层析图分割、标注与过滤；限制单粒子分析/断层扫描分辨率的因素二维和三维异构数据。Drs。D. Hanein和S. Ludtke担任会议主席。W. Chiu（美国）、E. Egelman（美国）、B. Hankamer（澳大利亚）、M. Kikkawa（日本）、D. Mastronarde（美国）、P. Penczek（美国）、H. Stahlberg（欧洲）、F. Sun（中国）和N. Volkmann（美国）是组委会成员。研讨会将进行广泛的宣传，并将尽可能实现组织者的包容性和多样性，并将允许100名参与者的限制。

DESCRIPTION (provided by applicant): The goal of this application is to convene a three-day Workshop on the cutting-edge topic of "Image Analysis in Three-Dimensional Cryo-Electron Microscopy" slated for early spring 2015. This would follow the 1st workshop, which will be held from March 12-15, 2014 at the Granlibakken Conference Center at Lake Tahoe, CA. The goal of the workshop is to bring together specialists in algorithm development to assess the state of the art in image analysis approaches that tackle challenging biological problems and to discuss current limitations and road blocks in the 3D cryo-EM field as currently practiced. The workshop will provide an open forum for developers in this area, both established as well as students/postdocs to consider the detailed algorithms and methodologies in this fast developing field and identify areas in the most need of concerted effort. The central premise of the workshop is that gaining a comprehensive and quantitative understanding of highly sophisticated biological machines, complexes, and organelles of the cell requires the active, timely and coordinated development of complementary image analysis and data mining algorithms and approaches. The program consists of one keynote lecture, five platform sessions with both invited talks (70%), and talks selected from submitted abstracts (30%), as well as two poster sessions. All sessions will focus on interactive discussions with plenty of time for questions. The 2014 meeting will include a special "Vision" talk on the "Past and future of image analysis methods" by David DeRosier, Brandeis University. The talks will survey new method development efforts combined with details on advances within more "traditional" imaging approaches. The current platform sessions for the 2014 meeting are: Map Validation; Single Particle Approaches to Helical Symmetry and 2-D Crystals; Direct Detector Movie Processing; Tomogram Segmentation, Annotation and Filtration; Factors Limiting Resolution in Single Particle Analysis/Tomography; Heterogeneous Data in 2-D and 3-D. Drs. D. Hanein and S. Ludtke serve as Chairs of the meeting and Drs. W. Chiu (US), E. Egelman (US), B. Hankamer (Australia), M. Kikkawa (Japan), D. Mastronarde (US), P. Penczek (US), H. Stahlberg (Europe), F. Sun (China), and N. Volkmann (US) are members of the organizing committee. The Workshop will be extensively advertised and will be as inclusive and diversity-sensitive as the organizers can achieve and the 100-participant limit will allow.