基质粘附力传导的超微结构基础-猫眼课题宝

基质粘附力传导的超微结构基础

批准号：

8550088

负责人：

DORIT HANEIN

金额：

$146.81万

依托单位：

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-09-30 至 2016-08-31

来源：

https://reporter.nih.gov/project-details/8550088

关键词：

Accounting Actins Actomyosin Address Adhesions Affect Affinity Avidity Basal Cell Behavior Binding Binding Sites Biochemical Biochemistry Biological Biological Models Biological Process Blood Vessels Caliber Cell Adhesion Cell Culture Techniques Cell Death Cell membrane Cell physiology Cell-Matrix Junction Cells Cellular biology Chemicals Chimeric Proteins Chronic Clinical Collagen Complex Computational Science Crystal Formation Crystallization Cytoskeleton Data Defect Dependence Development Devices Dimensions Disease Dissociation Electron Microscopy Electrons Elements Embryo Endothelial Cells Environment Event Exhibits Extracellular Matrix Feedback Fibroblasts Filament Fluorescence Fluorescence Microscopy Focal Adhesions Freezing Gel Generations Goals Half-Life Heterogeneity Homeostasis Ice Image Imaging Techniques In Situ In Vitro Individual Inflammatory Integrin Binding Integrin-mediated Cell Adhesion Pathway Integrins Knowledge Lateral Learning Length Life Ligands Light Link Mechanics Mediating Membrane Methods Microscopy Modeling Modification Molecular Molecular Conformation Monitor Monomeric GTP-Binding Proteins Morphology Mus Myosin ATPase Neoplasm Metastasis Output Pathway interactions Pattern Recognition Phenotype Phosphotransferases Physiological Principal Investigator Procedures Process Property Protein Dynamics Proteins Protocols documentation Psychological reinforcement Reagent Regulation Resolution Roentgen Rays Sampling Signal Pathway Signal Transduction Spectrum Analysis Stress Fibers Stretching Structure Study models System Talin Techniques Time Variant Vinculin Water Work X ray microscopy aqueous base cell behavior cell motility cellular imaging electron tomography extracellular human BCAR1 protein in vivo insight intercellular communication light microscopy macromolecule migration millisecond nanometer neuronal cell body novel paxillin programs receptor reconstruction research study response rho sample fixation single molecule stem tomography transmission process tumor

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DESCRIPTION (provided by applicant): The overall goal of this Program Project is to understand in detail how integrin-mediated adhesions mature and how this process determines signaling outputs. Adhesion maturation is highly dependent on physical forces, whether from endogenous myosin or applied externally through the extracellular matrix. Thus, comparison of normal adhesion ultrastructure and dynamics with responses to applied force will elucidate mechanisms of mechanotransduction. This Program Project will develop a model for mechanotransduction at matrix adhesions that integrates adhesion ultrastructure, biochemical interactions, temporal and spatial dynamics of multiprotein assemblies and signaling networks. We will analyze mechanotransduction in the context of cell migration as an important physiological output of adhesion mechanics and signaling. To achieve this, we have formed a unique team of long-standing collaborators who will implement a multifaceted experimental approach that includes molecular cell biology, biochemistry, biophysical approaches, material science, computational and mathematical analysis, and correlated high-resolution light and electron microscopy.

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