课题基金 / 基金详情

Structural basis of inflammasome assembly and regulation

Structural basis of inflammasome assembly and regulation
炎症小体组装和调节的结构基础
批准号：
8089765
负责人：
DORIT HANEIN
金额：
$42.98万
依托单位：
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-15 至 2011-06-30
来源：
https://reporter.nih.gov/project-details/8089765
关键词：
Acetylmuramyl-Alanyl-IsoglutamineAdaptor Signaling ProteinAddressApoptosisAutoimmune DiseasesAutoimmunityBenchmarkingBindingBiochemicalBiologicalBiological AssayC-terminalCaspaseCaspase-1Cell WallCellsCommunicable DiseasesComplexCrohn&aposs diseaseCryoelectron MicroscopyDiseaseElementsEquilibriumFamilyFamily memberGenesGenetic PolymorphismGenetic Predisposition to DiseaseGoalsHeredityHost DefenseHumanImage AnalysisImaging TechniquesImmuneImmune responseIn VitroIndividualInflammationInflammatoryInflammatory Bowel DiseasesInflammatory ResponseInheritedInvadedKnowledgeLeadLeucine-Rich RepeatLigand BindingLigandsLinkMethodologyMolecularMusMutationNatural ImmunityNucleotidesOrthologous GenePathway interactionsPhosphotransferasesPhysiologicalProcessProtein FamilyRecruitment ActivityRegulationResearch PersonnelResolutionRoleSeriesSignaling ProteinStructureSystemThree-Dimensional ImageToll-like receptorsToxinUlcerative ColitisVariantVitiligoanaloganthrax lethal factorbaseclinical phenotypecytokinedesignelectron tomographyextracellularimage reconstructionin vivoinsightkillingsmacrophagemonomermutantnovel therapeuticspathogenprocaspase-1protein complexprotein functionreceptorreconstitutionreconstructionresponsethree dimensional structuretomography

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