Alcohol, Mortality and Ethnicity in the US

描述(由申请者提供)：面试调查(NHIS)提供了一个独特的机会来探索酒精消费的不同方面与美国不同种族的全因和特定原因死亡率之间的关系。我们将检验以下具体假设：嗨：总体来说，45岁以上人群的平均饮酒量与全因死亡率之间将出现J型曲线，而年轻人的平均饮酒量与全因死亡率之间将出现直线曲线。H2：有大量饮酒场合的饮酒模式不会对所有原因的死亡率产生任何有益的影响。H3-4：基于各自的饮酒模式，平均饮酒量与全因死亡率之间的关系将因种族而异。H5-7：由于大量饮酒与冠心病和伤害有关，这些死因的特定死因与种族有关，而对于癌症，预计平均饮酒量与种族之间没有这种交互作用。NHIS是对非制度化的美国平民人口进行的具有代表性的横断面调查。对于1988年和1990年的国民健康保险制度，婚姻状况和基本死因适用于所有18岁及以上的成年人，跟踪调查将持续到1997年12月31日。基线样本将包括81,464名男性(n=33,989)和女性(47,475)，以及5,585名西班牙裔男性(n=2,303)和女性(3,282)和11,253名非西班牙裔黑人男性(n=3,983)和女性(7,270)。大约。8年的随访将包括总共8294例死亡，302例西班牙裔死亡和1223例非西班牙裔黑人死亡。这将是迄今为止最具代表性的美国样本，用于调查美国主要少数群体中酒精摄入量与死亡率之间的关联。一旦确定了样本的同质性，将对组合数据使用比例风险回归模型。这一结果将为制定针对种族的预防措施提供重要的背景数据，以避免与酒精有关的疾病负担。

DESCRIPTION (provided by applicant): Interview Survey (NHIS) offer a unique chance to explore the relationships between different dimensions of alcohol consumption with all-causes & cause-specific mortality in different ethnic groups in the US. The following specific hypotheses will be tested: HI: Overall, there will be a J-shaped curve between average volume of alcohol consumption & all-cause mortality in people over 45 years of age, & a linear curve in younger persons. H2: A drinking pattern with heavy drinking occasions will confer no beneficial effects on all-causes mortality. H3-4: The relationships between average volume of alcohol consumption & all-causes mortality will be specific to ethnicity, based on the respective drinking patterns. H5-7: As heavy drinking occasions are relevant for Coronary Heart Disease & injuries, the cause specific mortality for those causes of death with be ethnic group specific, whereas for cancers no such interaction between average volume of alcohol consumption and ethnicity is expected. The NHIS is a representative cross-sectional survey of the civilian, non-institutionalized US population. For the1988 & 1990 NHIS, marital status & underlying cause of death are available for all adults18 years & older with follow-up through 12/31/97. The baseline sample will include 81,464 men (n=33,989) & women (47,475) with 5,585 Hispanic men (n=2,303) & women (3,282) & 11,253 non-Hispanic Black men (n=3,983) & women (7,270). The approx. 8 years of follow-up will include a total of 8,294 deaths, 302 Hispanic deaths and 1,223 deaths in non-Hispanic Blacks. This will be the largest representative US sample to date used to investigate the association between dimensions of alcohol intake & mortality in the major US minority groups. Proportional hazard regression models will be used on the combined data, once homogeneity of samples is established. The results will provide important background data for shaping ethnicity-specific preventive measures for avoiding alcohol-related burden of disease.