Navigator coronary magnetic resonance

描述(由申请人提供)：这项研究的广泛目标是开发能够准确检测冠状动脉重大病变的磁共振成像(MRJ)技术。与CT和X光血管造影相比，MRI具有许多优点，包括不同组织之间丰富且可调节的对比度，非侵入性操作，不使用电离辐射，并且没有肾毒性的风险。先前的研究已经证明了同时成像冠脉管腔和冠状动脉壁的可行性，但诊断的准确性仍然受到运动伪影的影响。冠状动脉磁共振血管成像(MRA)技术正在迅速发展。前一个供资周期的研究得出了几个重要结论。SSFP序列因其高信噪比效率和快速成像速度而被认为是冠状动脉MRA的最佳序列。实时导航仪门控可为冠状动脉MRA提供比屏气检查更高的空间分辨率和图像质量。由于使用的是心电图和横隔膜导航仪回声，两者都不能直接测量冠状动脉的运动，所以在冠状动脉MRA的质量上仍然存在不一致。我们最近开发了冠状动脉脂肪导航仪方法，可以直接和准确地监测冠状动脉运动。因此，我们建议开发用于SSFP冠状动脉MRA的冠状动脉脂肪导航仪，以实现有效的运动抑制。我们还开发了一种用于高效导航选通的同步多体积(SMV)算法。初步数据表明，SMV算法将导航门控扫描时间缩短了2-3倍。因此，我们建议将SMV门控技术应用于导航仪冠状动脉MRA，以缩短扫描时间。我们还在冠状动脉壁成像方面取得了初步经验。在高分辨率斑块成像中，导航仪技术可以直接用于减少运动模糊伪影，这将为冠状动脉粥样硬化斑块的定性提供有价值的信息。本研究包括两个具体目标：1)开发一种高效、有效的冠状动脉管腔和管壁成像导航方法；2)通过与常规X线血管造影和血管内超声的比较，评价所开发的冠状动脉MRI在冠心病患者中的应用。

DESCRIPTION (provided by applicant): The broad objective of this research is to develop magnetic resonance imaging (MRJ) techniques that will accurately detect significant lesions in the coronary arteries. MRI offers many advantages over CT and x- ray angiography for imaging coronary artery disease, including rich and adjustable contrasts between different tissues, noninvasive procedures, no use of ionizing radiation, and no risk of nephrotoxicity. Prior studies have demonstrated the feasibility of imaging both the coronary lumen and wall, but diagnostic accuracy is still impaired by motion artifacts. Coronary MR Angiography (MRA) technology is rapidly evolving. Studies in the prior funding cycle have led to several key findings. SSFP has been identified as the best sequence for coronary MRA because of its high SNR efficiency and fast imaging speed. Real time navigator gating provides higher spatial resolution and image quality than breath-holding for coronary MRA. There is still inconsistency in coronary MRA quality because of the use of electrocardiogram and the diaphragm navigator echo, neither of which directly measures coronary motion. We have recently developed the coronary fat navigator method that allows direct and accurate monitoring of coronary motion. Accordingly, we propose here to develop the coronary fat navigator for SSFP coronary MRA to achieve effective motion suppression. We have also developed a simultaneous multiple volume (SMV) algorithm for efficient navigator gating. Preliminary data demonstrate that the SMV algorithm shortens navigator gated scan time by 2-3 fold. Accordingly, we propose to incorporate SMV gating into navigator coronary MRA to shorten scan time. We have also obtained preliminary experience in imaging coronary vessel walls. The navigator technology can be directly employed to reduce motion blurring artifacts in high resolution plaque imaging, which would provide valuable information for characterizing atherosclerotic plaque in coronary arteries. This research consists of two specific aims: 1) develop an efficient and effective navigator method for imaging the coronary lumen and wall; and 2) evaluate the developed coronary MRI in patients with coronary artery disease by comparing to conventional x-ray angiography and intravascular ultrasound.