Hormones in Sex-different Developmental Psychopathology

性别不同发育精神病理学中的激素

• 批准号: 6998454
• 负责人: JOEL T NIGG
• 金额: $ 15.87万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998454
• 关键词: adolescence (12-20); androgens; attention deficit disorder; behavioral /social science research tag; child psychology; children; clinical research; eating disorders; gender difference; hormone metabolism; hormone regulation /control mechanism; human puberty; hypothalamic hormones; hypothalamic pituitary adrenal axis; laboratory rat; neuropsychological tests; neuropsychology; pituitary hormones; psychopathology; questionnaires

DESCRIPTION (provided by applicant): This is an R-21 submission that responds to the need for translational research initiatives to apply basic science advances to clinical problems. The project would bring together a team of experienced basic scientists who are experts in hormones, behavior, and development with clinical researchers who study two different clinical syndromes at different levels of analysis. The clinical domains were selected for their distinctly different sex-risk profiles, and because for each domain hormone modulation of the disorder's behavioral expression has been hypothesized but not well-investigated: attention-deficit hyperactivity disorder (ADHD) and eating disorders (EDs). The team would also include expertise in animal models of learning, attention, and cognition, so that component mechanisms underlying behavioral expression can be examined. The team also includes expertise in hormone studies of psychiatric populations with depression. Expertise is also present in environmental hormone disrupting chemicals that are suspected by many scientists of altering cognitive and physical development in subtle ways. Thus, the team will have broad expertise that is designed to foster novel cross-cutting translational research planning and prioritizing in order to foster development of a coherent translational research agenda that can examine the contribution of hormones and hormone disruptors and neuromodulators to sex differences in behavioral expression of psychopathology in multiple domains. Regular meetings of this broadly composed team would be held to assure development of this agenda. In addition, under the award, key pilot studies will be conducted to examine (a) circulating hormonal correlates of cognitive and behavioral functioning in children, adolescents, and young adult males and females with ADHD, (b) hormone moderation of pubertal changes in eating disorder symptoms in a non-clinical human sample expected to be free of dietary disruption of hormonal status, (c) cognitive and affective correlates of background contaminant (PCB and DDE) exposures in clinical and non-clinical human samples using executive function probes not previously applied to this question, and (d) key animal experiments to evaluate whether hormonal effects can explain previously-observed sex differences in learning in animal models of ADHD. Expected outcomes of the award are knowledge about the feasibility and areas of greatest promise for these novel research directions, accompanied by a coherent translational research agenda that can culminate in additional cross-cutting research initiatives.

描述（由申请人提供）：这是R-21提交，响应了对转化研究计划的需求，以将基础科学进步应用于临床问题。该项目将汇集一个经验丰富的基础科学家团队，他们是临床研究人员，他们是激素，行为和发展专家，他们研究了两种不同分析水平的临床综合症。选择了其明显不同的性风险特征，并且由于对疾病的行为表达的每个域的激素调节而被选择，但已被假设，但没有得到充分评价：注意力缺陷多动症（ADHD）和饮食障碍（EDS）。该团队还将包括学习，注意力和认知的动物模型中的专业知识，以便可以检查行为表达的组成机制。该小组还包括抑郁症精神病学种群的激素研究专业知识。在环境激素破坏化学物质中也存在专业知识，这些化学物质被许多科学家怀疑以微妙的方式改变认知和身体发展。因此，该团队将拥有广泛的专业知识，旨在促进新颖的跨切换研究计划并确定优先级，以促进一个连贯的转化研究议程的发展，该议程可以研究激素和激素破坏者和神经调节剂对多个领域心理病理行为表达行为表达性别差异的贡献。将举行这个广泛组成的团队的定期会议，以确保该议程的发展。 In addition, under the award, key pilot studies will be conducted to examine (a) circulating hormonal correlates of cognitive and behavioral functioning in children, adolescents, and young adult males and females with ADHD, (b) hormone moderation of pubertal changes in eating disorder symptoms in a non-clinical human sample expected to be free of dietary disruption of hormonal status, (c) cognitive and affective correlates of background使用先前未应用于此问题的执行功能探针在临床和非临床人类样品中的污染物（PCB和DDE）暴露，（d）关键动物实验以评估激素效应是否可以解释ADHD动物模型中先前观察到的性别差异。该奖项的预期成果是有关这些新型研究方向的可行性和最大希望的知识，并伴随着连贯的转化研究议程，该议程可以在其他跨切割研究计划中达到顶峰。