The Epidemiology of Autism in a Low Birthweight Cohort

低出生体重人群中自闭症的流行病学

• 批准号: 7037313
• 负责人: JENNIFER A PINTO-MARTIN
• 金额: $ 37.17万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7037313
• 关键词: Asperger syndrome; autism; behavioral /social science research tag; brain injury; child mental disorders; clinical research; cognition; communication; communication disorders; disease /disorder proneness /risk; epidemiology; family genetics; human subject; longitudinal human study; low birth weight infant human; mental health epidemiology; patient oriented research; pregnancy infection; psychological adaptation; psychomotor function; psychopathology; questionnaires; social behavior; social behavior disorders; social psychology; ultrasonography; white matter

DESCRIPTION (provided by applicant): The goals of this study are to better characterize Autistic Spectrum Disorders (ASD) and social communication problems in low birthweight (LBW) survivors and to better understand the relation between pre, peri and neonatal complications, including brain injury to ASD and social and communication problems in this population. The study sample will be drawn from the Neonatal Brain Hemorrhage Study (NBHS) cohort, the largest regional LBW cohort screened with serial cranial ultrasound (US) ever to be assembled. The cohort was re-assessed at age 15-16 and parent report on screens for ASD (Social Communication Questionnaire and the Asperger Syndrome Screening Questionnaire) was obtained. We propose to rigorously evaluate for diagnosis all participants who screened positive for ASD and a sample of those who screened negative. The specific aims pursuant to this goal are: (1) to estimate, for this LBW population, the current prevalence of ASD and to compare this prevalence to those reported in general populations studies; (2) to systematically describe and compare, based on ASD screening status, the phenomenology and developmental history of those positive for an ASD diagnosis (ASD True Positives), those positive on the ASD screen but not diagnostically positive for ASD (ASD False Positives) and those who were negative on the ASD screen as adolescents and negative for ASD upon diagnostic evaluation as well (Controls). The domains described and compared will include both the core domains affected in ASD (social interaction, communication and interests) and associated features (cognition, motor function, adaptive behavior, minor physical anomalies) (3) to examine predictors of ASD true positives and separately, predictors of ASD false positives using the extensive set of specific pre-, peri- and neonatal complications available from the original NBHS study; including indices of maternal infection and cranial US evidence of white matter injury (4) to examine the relation of family loading for psychiatric disorder to ASD true positive status and ASD false positives status, (5) to estimate, for this LBW population, the screening properties of the SCQ and the ASSQ for ASD true positives, ASD false positives and controls. This application has the potential to yield important information about ASD and social and communication problems in LBW survivors. In addition to describing the prevalence and presentation of ASD in LBW survivors, it will elucidate etiologic mechanisms that may inform prevention and treatment of ASD and social and communication problems in the general population.

描述（由申请人提供）：本研究的目标是更好地表征低出生体重（LBW）幸存者的自闭症谱系障碍（ASD）和社会沟通问题，并更好地了解该人群中ASD，ASD和社会问题的脑损伤和新生儿并发症之间的关系。研究样本将从新生儿脑出血研究（NBHS）队列中得出，这是有史以来最大的区域LBW队列，并筛选出有史以来串行颅骨超声（US）。该队列在15-16岁时重新评估，并在ASD的屏幕上报告（社会传播问卷和Asperger综合征筛查问卷）。我们建议对诊断进行严格评估所有对ASD筛选呈阳性的参与者以及筛选阴性的人的样本。根据这一目标的具体目的是：（1）为了估计，对于LBW人群，当前ASD的患病率并将这种流行率与一般人口研究中报告的率进行比较； （2）基于ASD筛查状态，系统地描述和比较ASD诊断阳性的人的现象学和发展历史（ASD真实的），在ASD屏幕上呈阳性，但对ASD（ASD误报）的诊断（ASD误报）并非诊断为阳性（ASD误报）以及对ASD屏幕为aSD屏幕的人，以及对ASD的负面诊断，以及对ASD的负面诊断，以及对ASD的负面评估。所描述和比较的领域将包括在ASD（社交互动，沟通和兴趣）中受影响的核心领域以及相关特征（认知，运动功能，适应性行为，次要身体异常）（3），以检查ASD真实积极的预测因素，并分别使用ASD假阳性的预测指标，使用ASD假阳性的预测指标，使用特定的前，周期和新的nectional nections nections conterive;包括孕产妇感染和颅美国关于白质损伤的证据（4），以检查精神疾病的家庭负载与ASD的真正正面状态和ASD误报状态的关系，（5）估算，对于LBW人群，SCQ的筛查特性和ASD的ASD aSD prime for ASD阳性，ASD的误报，ASD的效果，ASD误差的阳性和对照。该应用程序有可能在LBW幸存者中产生有关ASD以及社会和沟通问题的重要信息。除了描述LBW幸存者中ASD的患病率和表现外，它将阐明病因机制，这些机制可能为预防和治疗ASD的一般人群中的预防和治疗提供依据。