The Epidemiology of Autism in a Low Birthweight Cohort

低出生体重人群中自闭症的流行病学

• 批准号: 7339038
• 负责人: JENNIFER A PINTO-MARTIN
• 金额: $ 31.8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7339038
• 关键词: Adaptive Behaviors; Adolescent; Affect; Age; Antibiotics; Asperger Syndrome; Autistic Disorder; Birth; Bladder; Blood; Brain Injuries; Brain hemorrhage; Cephalic; Cerebral Palsy; Child; Clinical; Cognition; Cognitive; Cohort Studies; Communication; Condition; Data; Development; Diagnosis; Diagnostic; Disease; Epidemiology; Evaluation; Family; Family Relationship; Family history of; Female; Fever; Gender; General Population; Goals; Hospitals; Impairment; Individual; Infant; Infection; Infection of amniotic sac and membranes; Interview; Laboratories; Language; Language Disorders; Learning Disabilities; Low Birth Weight Infant; Mediating; Mental Retardation; Mental disorders; Minor; Mood Disorders; Mothers; Motor; Neonatal; Neonatal Intensive Care; Neurologic; Not Otherwise Specified; Parents; Participant; Perinatal; Pervasive Development Disorder; Population; Population Study; Predictive Value; Prevalence; Prevention; Property; Questionnaires; Rate; Recording of previous events; Reporting; Research Personnel; Risk Factors; Sampling; Sampling Studies; Score; Screening procedure; Seizures; Sensitivity and Specificity; Social Interaction; Social Phobia; Survivors; Time; Ultrasonography; Urine; autism spectrum disorder; base; case control; cohort; design; disability; follow-up; indexing; instrument; interest; male; medical complication; prenatal; programs; prospective; respiratory gas; social communication; social skills; white matter injury

DESCRIPTION (provided by applicant): The goals of this study are to better characterize Autistic Spectrum Disorders (ASD) and social communication problems in low birthweight (LBW) survivors and to better understand the relation between pre, peri and neonatal complications, including brain injury to ASD and social and communication problems in this population. The study sample will be drawn from the Neonatal Brain Hemorrhage Study (NBHS) cohort, the largest regional LBW cohort screened with serial cranial ultrasound (US) ever to be assembled. The cohort was re-assessed at age 15-16 and parent report on screens for ASD (Social Communication Questionnaire and the Asperger Syndrome Screening Questionnaire) was obtained. We propose to rigorously evaluate for diagnosis all participants who screened positive for ASD and a sample of those who screened negative. The specific aims pursuant to this goal are: (1) to estimate, for this LBW population, the current prevalence of ASD and to compare this prevalence to those reported in general populations studies; (2) to systematically describe and compare, based on ASD screening status, the phenomenology and developmental history of those positive for an ASD diagnosis (ASD True Positives), those positive on the ASD screen but not diagnostically positive for ASD (ASD False Positives) and those who were negative on the ASD screen as adolescents and negative for ASD upon diagnostic evaluation as well (Controls). The domains described and compared will include both the core domains affected in ASD (social interaction, communication and interests) and associated features (cognition, motor function, adaptive behavior, minor physical anomalies) (3) to examine predictors of ASD true positives and separately, predictors of ASD false positives using the extensive set of specific pre-, peri- and neonatal complications available from the original NBHS study; including indices of maternal infection and cranial US evidence of white matter injury (4) to examine the relation of family loading for psychiatric disorder to ASD true positive status and ASD false positives status, (5) to estimate, for this LBW population, the screening properties of the SCQ and the ASSQ for ASD true positives, ASD false positives and controls. This application has the potential to yield important information about ASD and social and communication problems in LBW survivors. In addition to describing the prevalence and presentation of ASD in LBW survivors, it will elucidate etiologic mechanisms that may inform prevention and treatment of ASD and social and communication problems in the general population.

描述(由申请人提供)：这项研究的目标是更好地描述低出生体重(LBW)幸存者的自闭症谱系障碍(ASD)和社交问题，并更好地了解产前、围产期和新生儿并发症之间的关系，包括ASD的脑损伤以及这一人群中的社交和沟通问题。研究样本将来自新生儿脑出血研究(NBHS)队列，这是有史以来用连续颅脑超声(US)筛查的最大的地区性LBW队列。在15-16岁时对队列进行重新评估，并获得ASD筛查的父母报告(社交沟通问卷和Asperger综合征筛查问卷)。我们建议严格评估所有ASD筛查阳性的参与者和筛查阴性的样本进行诊断。根据这一目标，具体目标是：(1)估计这一LBW人群目前ASD的患病率，并将这一患病率与一般人口研究中报告的患病率进行比较；(2)基于ASD筛查状况，系统地描述和比较ASD诊断阳性者(ASD真阳性)、ASD筛查阳性但ASD诊断不阳性者(ASD假阳性)和ASD青少年筛查阴性且ASD诊断评估后ASD阴性者(对照组)的现象学和发育史。描述和比较的领域将包括影响ASD的核心领域(社交、交流和兴趣)和相关特征(认知、运动功能、适应行为、轻微的身体异常)(3)检查ASD真阳性的预测因素，并分别使用原始NBHS研究中提供的大量特定的前、围产期和新生儿并发症来检查ASD假阳性的预测因素；包括母体感染指数和脑白质损伤的头颅超声证据(4)检查精神障碍的家庭负荷与ASD真阳性和ASD假阳性状态的关系，(5)估计SCQ和ASSQ对ASD真阳性、ASD假阳性和对照的筛查特性。这项应用有可能提供有关自闭症以及LBW幸存者的社会和沟通问题的重要信息。除了描述ASD在LBW幸存者中的患病率和表现外，它还将阐明可能为预防和治疗ASD以及普通人群中的社会和沟通问题提供信息的病因机制。