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Ferritin binding and signalling receptors in hepatic fibrogenesis.

Ferritin binding and signalling receptors in hepatic fibrogenesis.
肝纤维发生中的铁蛋白结合和信号传导受体。
批准号:
nhmrc : GNT1064533
负责人:
Prof Darrell Crawford
金额:
$50.16万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

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中文摘要
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英文摘要
Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology, the cells responsible for liver scarring (fibrosis) in Haemochromatosis. This proposal will identify the receptor responsible for eliciting ferritin's proinflammatory action and assess its role in fibrosis. This study will have implications in chronic liver diseases of varying aetiologies where elevated serum ferrritin is associated with inflammation.
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会议论文
Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.
  • 批准号:
    nhmrc : GNT1142394
  • 项目类别:
    Project Grants
  • 资助金额:
    $78.36万
  • 财政年份:
    2018
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.
  • 批准号:
    nhmrc : 1142394
  • 项目类别:
    Project Grants
  • 资助金额:
    $52.98万
  • 财政年份:
    2018
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Tissue ferritin acts as a proinflammatory mediator of hepatic fibrosis in chronic liver disease via multiple receptors in hepatic stellate cells responsible for both binding and signalling.
  • 批准号:
    nhmrc : 1064533
  • 项目类别:
    Project Grants
  • 资助金额:
    $51.87万
  • 财政年份:
    2014
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Advanced imaging to define hepatic & intestinal drug disposition in aging & liver diseases
  • 批准号:
    nhmrc : 1049979
  • 项目类别:
    Project Grants
  • 资助金额:
    $50.82万
  • 财政年份:
    2013
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
国内基金
海外基金
BRD4通过结合TEAD1调控β细胞增殖分化的机制研究
  • 批准号:
    82370801
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    李峰
  • 依托单位:
PCBP1和PCBP2调控cGAS的相变和酶活的机制研究
  • 批准号:
    32370928
  • 项目类别:
    面上项目
  • 资助金额:
    50.00万元
  • 批准年份:
    2023
  • 负责人:
    孙钦秒
  • 依托单位:
帽结合蛋白(cap binding protein)调控乙烯信号转导的分子机制
  • 批准号:
    32170319
  • 项目类别:
    面上项目
  • 资助金额:
    58.00万元
  • 批准年份:
    2021
  • 负责人:
    董春海
  • 依托单位:
帽结合蛋白(cap binding protein)调控乙烯信号转导的分子机制
  • 批准号:
    --
  • 项目类别:
    --
  • 资助金额:
    58万元
  • 批准年份:
    2021
  • 负责人:
    董春海
  • 依托单位: