Ferritin binding and signalling receptors in hepatic fibrogenesis.

肝纤维发生中的铁蛋白结合和信号传导受体。

• 批准号: nhmrc : GNT1064533
• 负责人: Prof Darrell Crawford
• 金额: $ 50.16万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ferritin-binding-signalling-hepatic-fibrogenesis/1344870
• 关键词: Ferritin; binding; signalling; receptors; hepatic

Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology, the cells responsible for liver scarring (fibrosis) in Haemochromatosis. This proposal will identify the receptor responsible for eliciting ferritin's proinflammatory action and assess its role in fibrosis. This study will have implications in chronic liver diseases of varying aetiologies where elevated serum ferrritin is associated with inflammation.

我们的研究确定了组织源性铁蛋白作为促炎细胞因子在肝星状细胞生物学中的作用，肝星状细胞是血色素沉着症中导致肝脏疤痕（纤维化）的细胞。该提案将鉴定负责引发铁蛋白促炎作用的受体并评估其在纤维化中的作用。这项研究将对不同病因的慢性肝病产生影响，其中血清铁蛋白升高与炎症相关。