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Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.

Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.
组织铁蛋白是炎症小体诱导的炎症中的一种损伤相关分子模式 (DAMP),与慢性肝病中的肝星状细胞活化和纤维形成相关。
批准号:
nhmrc : 1142394
负责人:
Prof Darrell Crawford
金额:
$52.98万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
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英文摘要
We have generated considerable evidence for a role for tissue ferritin as a mediator of inflammation associated with liver fibrosis (scarring) These highly novel and innovative studies will assist in identifying pathways involved in the proinflammatory phenotype of hepatic stellate cells (scar-forming cells in the liver) in chronic liver disease and thus will greatly aid in understanding how liver scarring occurs in chronic liver disease.
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会议论文
Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.
  • 批准号:
    nhmrc : GNT1142394
  • 项目类别:
    Project Grants
  • 资助金额:
    $78.36万
  • 财政年份:
    2018
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Ferritin binding and signalling receptors in hepatic fibrogenesis.
  • 批准号:
    nhmrc : GNT1064533
  • 项目类别:
    Project Grants
  • 资助金额:
    $50.16万
  • 财政年份:
    2014
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Tissue ferritin acts as a proinflammatory mediator of hepatic fibrosis in chronic liver disease via multiple receptors in hepatic stellate cells responsible for both binding and signalling.
  • 批准号:
    nhmrc : 1064533
  • 项目类别:
    Project Grants
  • 资助金额:
    $51.87万
  • 财政年份:
    2014
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Advanced imaging to define hepatic & intestinal drug disposition in aging & liver diseases
  • 批准号:
    nhmrc : 1049979
  • 项目类别:
    Project Grants
  • 资助金额:
    $50.82万
  • 财政年份:
    2013
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
国内基金
海外基金
基于超声空化选择性降解瘤内Ferritin增效三阴性乳腺癌铁死亡的基础研
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    谢卓晏
  • 依托单位:
小分子抑制剂Thiotert通过TRX-NCOA4-FTH通路调控MDS细胞铁死亡
  • 批准号:
    LBY23H080005
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2023
  • 负责人:
    杜璟
  • 依托单位:
柑橘木虱Ferritin、Transferrin调控CLas侵染及逃避宿主防御机制的研究
  • 批准号:
    32302346
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    刘映雪
  • 依托单位:
H2O2调控黄曲霉ferritin基因表达抑制铁死亡的分子机制
  • 批准号:
    32302028
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    姚丽姗
  • 依托单位: