Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.

组织铁蛋白是炎症小体诱导的炎症中的一种损伤相关分子模式 (DAMP)，与慢性肝病中的肝星状细胞活化和纤维形成相关。

• 批准号: nhmrc : GNT1142394
• 负责人: Prof Darrell Crawford
• 金额: $ 78.36万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tissue-ferritin-damage-liver-disease/1348448
• 关键词: Tissue; ferritin; damage; associated; molecular

We have generated considerable evidence for a role for tissue ferritin as a mediator of inflammation associated with liver fibrosis (scarring) These highly novel and innovative studies will assist in identifying pathways involved in the proinflammatory phenotype of hepatic stellate cells (scar-forming cells in the liver) in chronic liver disease and thus will greatly aid in understanding how liver scarring occurs in chronic liver disease.

我们已经产生了相当多的证据证明组织铁蛋白作为与肝纤维化（瘢痕形成）相关的炎症介质的作用。这些非常新颖和创新的研究将有助于确定参与慢性肝病中肝星状细胞（肝脏中的瘢痕形成细胞）促炎表型的途径，从而极大地有助于理解慢性肝病中肝脏瘢痕形成的发生。