Tissue ferritin acts as a proinflammatory mediator of hepatic fibrosis in chronic liver disease via multiple receptors in hepatic stellate cells responsible for both binding and signalling.

组织铁蛋白通过肝星状细胞中负责结合和信号传导的多个受体，充当慢性肝病中肝纤维化的促炎介质。

• 批准号: nhmrc : 1064533
• 负责人: Prof Darrell Crawford
• 金额: $ 51.87万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tissue-ferritin-acts-binding-signalling/455124
• 关键词: Tissue; ferritin; acts; proinflammatory; mediator

Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology, the cells responsible for liver scarring (fibrosis) in Haemochromatosis. This proposal will identify the receptor responsible for eliciting ferritin's proinflammatory action and assess its role in fibrosis. This study will have implications in chronic liver diseases of varying aetiologies where elevated serum ferrritin is associated with inflammation.

我们的研究已经确定了组织来源的铁蛋白在肝星状细胞生物学中作为促炎细胞因子的作用，肝星状细胞是血色病中负责肝瘢痕形成（纤维化）的细胞。这项提议将确定负责引发铁蛋白的促炎作用的受体，并评估其在纤维化中的作用。这项研究将对不同病因的慢性肝病产生影响，其中血清铁蛋白升高与炎症相关。