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Tissue ferritin acts as a proinflammatory mediator of hepatic fibrosis in chronic liver disease via multiple receptors in hepatic stellate cells responsible for both binding and signalling.

Tissue ferritin acts as a proinflammatory mediator of hepatic fibrosis in chronic liver disease via multiple receptors in hepatic stellate cells responsible for both binding and signalling.
组织铁蛋白通过肝星状细胞中负责结合和信号传导的多个受体,充当慢性肝病中肝纤维化的促炎介质。
批准号:
nhmrc : 1064533
负责人:
Prof Darrell Crawford
金额:
$51.87万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

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中文摘要
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英文摘要
Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology, the cells responsible for liver scarring (fibrosis) in Haemochromatosis. This proposal will identify the receptor responsible for eliciting ferritin's proinflammatory action and assess its role in fibrosis. This study will have implications in chronic liver diseases of varying aetiologies where elevated serum ferrritin is associated with inflammation.
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会议论文
Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.
  • 批准号:
    nhmrc : GNT1142394
  • 项目类别:
    Project Grants
  • 资助金额:
    $78.36万
  • 财政年份:
    2018
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and fibrogenesis in chronic liver disease.
  • 批准号:
    nhmrc : 1142394
  • 项目类别:
    Project Grants
  • 资助金额:
    $52.98万
  • 财政年份:
    2018
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Ferritin binding and signalling receptors in hepatic fibrogenesis.
  • 批准号:
    nhmrc : GNT1064533
  • 项目类别:
    Project Grants
  • 资助金额:
    $50.16万
  • 财政年份:
    2014
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
Advanced imaging to define hepatic & intestinal drug disposition in aging & liver diseases
  • 批准号:
    nhmrc : 1049979
  • 项目类别:
    Project Grants
  • 资助金额:
    $50.82万
  • 财政年份:
    2013
  • 负责人:
    Prof Darrell Crawford
  • 依托单位:
国内基金
海外基金
基于超声空化选择性降解瘤内Ferritin增效三阴性乳腺癌铁死亡的基础研
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    谢卓晏
  • 依托单位:
小分子抑制剂Thiotert通过TRX-NCOA4-FTH通路调控MDS细胞铁死亡
  • 批准号:
    LBY23H080005
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2023
  • 负责人:
    杜璟
  • 依托单位:
柑橘木虱Ferritin、Transferrin调控CLas侵染及逃避宿主防御机制的研究
  • 批准号:
    32302346
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    刘映雪
  • 依托单位:
H2O2调控黄曲霉ferritin基因表达抑制铁死亡的分子机制
  • 批准号:
    32302028
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    姚丽姗
  • 依托单位: