Advanced imaging to define hepatic & intestinal drug disposition in aging & liver diseases

先进的成像技术来定义肝脏

• 批准号: nhmrc : 1049979
• 负责人: Prof Darrell Crawford
• 金额: $ 50.82万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/advanced-imaging-define-liver-diseases/112130
• 关键词: Advanced; imaging; define; hepatic; intestinal

Aged people and liver disease patients have impaired drug absorption and elimination functions. Their response to drugs varies widely when given drug dosage regimens recommended for normal patients. This project will explore the possibility of using in vivo imaging techniques to define the gut and liver function and their response to administered drugs. This grant will help the selection of appropriate drugs and doses for aged people and patients with liver diseases, i.e. personalised medicine.

老年人和肝病患者的药物吸收和排泄功能受损。当给予正常患者推荐的药物剂量方案时，他们对药物的反应差异很大。该项目将探索使用体内成像技术来确定肠道和肝脏功能及其对药物的反应的可能性。这笔赠款将帮助老年人和肝病患者选择适当的药物和剂量，即个性化药物。