ZEBRAFISH INTERNATIONAL RESOURCE CENTER

斑马鱼国际资源中心

• 批准号: 7255860
• 负责人: Monte Westerfield
• 金额: $ 2.3万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7255860
• 关键词: ZEBRAFISH; INTERNATIONAL; RESOURCE; CENTER

DESCRIPTION (provided by applicant): Zebrafish has emerged as a premiere organism to study vertebrate development and genetics. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology, and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish Iinternational Resource Center has been established as a repository that provides animals, materials, and services to the research community. This proposal seeks continued funding to: 1) provide a centralized repository for zebrafish genetic stocks and research materials; 2) provide consultation and pathology services; and 3) develop improved zebrafish husbandry methods. These materials, services, and information will be made widely available to the research community.

描述(由申请人提供)： 斑马鱼已经成为研究脊椎动物发育和遗传学的首选生物。强大的技术可以有效地产生和恢复斑马鱼突变，影响调控发育模式、器官发生、生理和行为的基因。最近的进展使得研究转基因斑马鱼和反义寡核苷酸的基因功能变得容易。这些基因中的许多功能在脊椎动物群体中是保守的。因此，对斑马鱼突变的分析提供了对包括人类在内的其他脊椎动物基因功能的洞察。斑马鱼国际资源中心已经建立，作为一个向研究界提供动物、材料和服务的储存库。这项提议寻求继续提供资金：1)提供斑马鱼遗传种群和研究材料的中央储存库；2)提供咨询和病理服务；以及3)发展改进的斑马鱼饲养方法。这些材料、服务和信息将广泛提供给研究界。