ZEBRAFISH INTERNATIONAL RESOURCE CENTER

描述（由申请人提供）： 斑马鱼已经成为研究脊椎动物发育和遗传学的首要生物。 强大的技术可以有效地产生和恢复影响基因的斑马鱼突变，调节发育模式，器官发生，生理和行为。 最近的进展使得在转基因斑马鱼和反义寡核苷酸中研究基因功能变得容易。 这些基因中的许多基因的功能在脊椎动物群体中是保守的。 因此，对斑马鱼突变的分析提供了对其他脊椎动物（包括人类）基因功能的见解。 斑马鱼国际资源中心是一个为研究界提供动物、材料和服务的资源库。 该提案寻求继续提供资金，以：1）为斑马鱼遗传种群和研究材料提供一个集中储存库; 2）提供咨询和病理学服务; 3）开发改进的斑马鱼饲养方法。 这些材料、服务和信息将广泛提供给研究界。

DESCRIPTION (provided by applicant): Zebrafish has emerged as a premiere organism to study vertebrate development and genetics. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology, and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish Iinternational Resource Center has been established as a repository that provides animals, materials, and services to the research community. This proposal seeks continued funding to: 1) provide a centralized repository for zebrafish genetic stocks and research materials; 2) provide consultation and pathology services; and 3) develop improved zebrafish husbandry methods. These materials, services, and information will be made widely available to the research community.