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Zebrafish International Resource Center

斑马鱼国际资源中心

基本信息

批准号：
8129491
负责人：
Monte Westerfield
金额：
$ 193.62万
依托单位：
UNIVERSITY OF OREGON
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-05-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8129491
关键词：
Adolescent Adult Affect Animals Antibodies Antisense Oligonucleotides Bacteriology Behavior Behavioral Genetics Breeding Collection Communities Consultations Cryopreservation Development Diagnosis Diagnostic Services Diet Disease Early Diagnosis Fertility Fishes Freezing Funding Generations Genes Genetic Genetic Variation Genotype Growth Health Status Hereditary Disease Histopathology Housing Human IACUC Information Services International Laboratories Laboratory Research Manuals Methods Monitor Mutation Organism Organogenesis Pathology Pattern Physiology Prevention Procedures Quality Control Recovery Research Resources Sentinel Services Shipping Ships Techniques Testing Transgenic Organisms Update Vertebrates Water Zebrafish disorder control gene function improved insight model organisms databases mutant mutation carrier reconstitution repository reproductive longevity sperm cell virology

项目摘要

DESCRIPTION (provided by applicant): Zebrafish is a premiere organism to study vertebrate development, physiology, behavior, genetics and disease. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many, if not most, of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish International Resource Center has been established as a repository that provides animals, materials and services to the research community. This proposal seeks continued funding 1) to provide a centralized repository for zebrafish genetic stocks and research materials; 2) to provide consultation and pathology services; and 3) to develop improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.

描述(申请人提供)：斑马鱼是研究脊椎动物发育、生理、行为、遗传和疾病的首选生物。强大的技术可以有效地产生和恢复斑马鱼突变，影响调控发育模式、器官发生、生理和行为的基因。最近的进展使得研究转基因斑马鱼和反义寡核苷酸的基因功能变得容易。这些基因中的许多(如果不是大多数)的功能在脊椎动物群体中是保守的。因此，对斑马鱼突变的分析提供了对包括人类在内的其他脊椎动物基因功能的洞察。斑马鱼国际资源中心已经建立，作为一个向研究界提供动物、材料和服务的储存库。这项建议寻求继续提供资金：1)提供斑马鱼遗传种群和研究材料的中央储存库；2)提供咨询和病理服务；3)开发改进的斑马鱼饲养方法。这些材料、服务和信息将向研究界广泛提供。