Coronary arterial dynamics and atherogenesis

冠状动脉动力学和动脉粥样硬化形成

• 批准号: 7107897
• 负责人: J SCOTT VANEPPS
• 金额: $ 3.4万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7107897
• 关键词: apoptosis; atherosclerosis; biomarker; biomechanics; cell proliferation; computational biology; coronary artery; fluid flow; histology; inflammation; lipids; luminescence; mechanical stress; organ culture; perfusion; predoctoral investigator; shear stress; swine; western blottings

DESCRIPTION (provided by applicant): Although risk factors for atherosclerosis (AS) are systemic in nature, certain arteries (e.g. coronary arteries) are more susceptible to AS than others. The coronary arteries experience the added mechanical forces of cyclic flexing, stretching and twisting due to their tethering to a beating heart suggesting that both shear and mural stress are contributors to AS. Hypothesis: Local variations in shear and mural stress associated with dynamic motion of arterial segments influence the distribution of early markers of atherogenesis. Specific Aims: (1) Determine experimentally the extent and spatial distribution of early markers (i.e. endothelial injury, lipid accumulation, and inflammatory activation) of atherogenesis in intact arterial segments exposed to physiologically realistic ex vivo perfusion conditions including cyclic flexure, stretch and twist; (2) Estimate the shear and mural stress distributions specifically for each experimentally perfused arterial segment using computational fluid dynamics and computational solid stress analyses, respectively; (3) Determine the correlative relationships between the shear and mural stress distributions estimated computationally and the spatial variation of atherogenic endpoints determined experimentally.

描述（由申请人提供）：尽管动脉粥样硬化的风险因素（AS）本质上是系统性的，但某些动脉（例如冠状动脉）比其他动脉更容易受到AS的影响。冠状动脉经历了循环弯曲，拉伸和扭曲的额外的机械力，因为它们的束缚在跳动的心脏上，这表明剪切和壁画应力都是AS的贡献者。假设：与动脉片段动态运动相关的剪切和壁应力的局部变化会影响动脉粥样硬化的早期标志物的分布。具体目的：（1）通过实验确定早期标志物（即内皮损伤，脂质积累和炎症激活）在完整动脉片段中暴露于生理上逼真的离体灌注条件，包括环状屈曲，伸展和扭曲的完整动脉片段中动脉粥样硬化片段中动脉粥样硬化的范围和空间分布； （2）分别使用计算流体动力学和计算固体应力分析分别针对每个实验性灌注的动脉段专门估算剪切和壁画应力分布； （3）确定剪切应力分布之间的相关关系估计计算，以及通过实验确定的动脉粥样硬化终点的空间变化。

项目成果

A new three-dimensional exponential material model of the coronary arterial wall to include shear stress due to torsion.

• DOI: 10.1115/1.2948396
• 发表时间: 2008-10
• 期刊: Journal of biomechanical engineering
• 作者: J. Van Epps;D. Vorp

Design and validation of a system to simulate coronary flexure dynamics on arterial segments perfused ex vivo.

设计和验证模拟体外灌注动脉段冠状动脉弯曲动力学的系统。

• DOI: 10.1007/s10237-007-0117-7
• 发表时间: 2009
• 期刊: Biomechanics and modeling in mechanobiology
• 影响因子: 3.5
• 作者: VanEpps,JScott;Londono,Ricardo;Nieponice,Alejandro;Vorp,DavidA
• 通讯作者: Vorp,DavidA