Language and Motor Interactions in Parkinson's Disease

描述（由申请人提供）：本项目的中心目标是研究帕金森病（PD）患者语言需求增加对言语产生的影响。言语障碍在PD中很常见；然而，语言产生的研究主要集中在感知特征上，而不是语言障碍背后的复杂发音运动。此外，尽管PD患者的语音清晰度在较长时间的生产过程中明显下降，但对这一人群的语音运动学的少数研究通常是基于音节、非单词或单词级的生产任务。为了理解PD对言语运动的影响，必须考虑到话语的语言结构和目的。因此，将收集15名PD患者和15名年龄和性别匹配的神经正常成人在不同长度和语言复杂性的说话任务中的上唇、下唇和下颌的发音运动数据。语言运动控制的测量，语言评估的行为数据，以及言语可理解性的感知评估将被分析，以便对PD如何影响交流做出全面的贡献。这项工作将对理解与言语产生相关的神经过程具有重要意义，也将对PD的诊断和治疗方法具有重要意义。

DESCRIPTION (provided by applicant): The central aim of this project is to investigate the effects of increased linguistic demands on speech production in individuals with Parkinson's disease (PD). Speech disturbances are common in PD; however, studies of speech production have primarily focused on perceptual characteristics, instead of on the complex articulatory movements underlying the speech disorder. Furthermore, although a decrease in speech intelligibility is evident during longer productions in individuals with PD, the few studies of speech kinematics in this population were generally based on syllable, non-word, or word-level production tasks. In order to understand how speech movements are affected by PD, it is essential to take into account the linguistic structure and goals of the utterance. Therefore, articulatory movement data from the upper lip, lower lip, and jaw will be collected from 15 individuals with PD and 15 age- and sex-matched neurologically normal adults during speaking tasks that vary in length and linguistic complexity. Measures of speech motor control, behavioral data from language assessments, and perceptual evaluations of speech intelligibility will be analyzed in order to contribute to a comprehensive profile of how communication is affected by PD. This work will have significance for understanding the neural processes related to speech production, and will also have important implications for diagnostic and therapeutic approaches to PD.