Language and Motor Interactions in Parkinson's Disease

帕金森病的语言和运动相互作用

• 批准号: 6936907
• 负责人: BRIDGET M WALSH
• 金额: $ 3.92万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936907
• 关键词: Language; Motor; Interactions; Parkinson; Disease

DESCRIPTION (provided by applicant): The central aim of this project is to investigate the effects of increased linguistic demands on speech production in individuals with Parkinson's disease (PD). Speech disturbances are common in PD; however, studies of speech production have primarily focused on perceptual characteristics, instead of on the complex articulatory movements underlying the speech disorder. Furthermore, although a decrease in speech intelligibility is evident during longer productions in individuals with PD, the few studies of speech kinematics in this population were generally based on syllable, non-word, or word-level production tasks. In order to understand how speech movements are affected by PD, it is essential to take into account the linguistic structure and goals of the utterance. Therefore, articulatory movement data from the upper lip, lower lip, and jaw will be collected from 15 individuals with PD and 15 age- and sex-matched neurologically normal adults during speaking tasks that vary in length and linguistic complexity. Measures of speech motor control, behavioral data from language assessments, and perceptual evaluations of speech intelligibility will be analyzed in order to contribute to a comprehensive profile of how communication is affected by PD. This work will have significance for understanding the neural processes related to speech production, and will also have important implications for diagnostic and therapeutic approaches to PD.

描述（由申请人提供）：该项目的核心目的是调查语言需求增加对帕金森氏病（PD）患者言语产生的影响。语音障碍在PD中很常见；但是，言语产生的研究主要集中在感知特征上，而不是言语障碍背后的复杂关节运动。此外，尽管在PD的个体长期生产过程中，语音清晰度的降低是显而易见的，但该人群中语音运动学的少数研究通常基于音节，非字或单词级生产任务。为了了解语音运动如何受到PD的影响，必须考虑到语言的结构和目的。因此，将从15个患有PD的人和15个年龄和性别匹配的神经学正常成年人的倾角，下唇和下巴的关节运动数据收集，在长度和语言复杂性各不相同。将分析语音运动控制，语言评估的行为数据以及对语音清晰度的感知评估的衡量标准，以促进对PD如何影响沟通的全面概念。这项工作对于理解与语音产生相关的神经过程具有重要意义，并且对PD的诊断和治疗方法也具有重要意义。