3DX: A Micromachined Silicon Crystallographic Detector

3DX：微机械硅晶体探测器

• 批准号: 7033269
• 负责人: EDWIN M WESTBROOK
• 金额: $ 55.04万
• 依托单位: MOLECULAR BIOLOGY CONSORTIUM
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-13 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7033269
• 关键词: X ray; X ray crystallography; bioimaging /biomedical imaging; biosensor device; computer program /software; crystallins; electric field; electrodes; model design /development; monitoring device; printing; robotics; silicon; synchrotrons; technology /technique development; temperature

DESCRIPTION (provided by applicant): We propose to continue development of the "3DX" silicon pixel array detector, in which diffracted X rays are captured directly in thick, high-resistivity silicon, micromachined by inductively-coupled plasma etching. Each pixel is 150x150mu m with one n- and one p-type electrode, and it is bonded with a conducting (indium) bump to a corresponding pixel of a CMOS readout chip, located behind the sensor. Each silicon sensor is an array of 64x64 pixels (total size: 9.6mmx9.6mm). In our design the sensor wafer is active to the very edge. Overlapping arrays of these sensors therefore have no dead gaps. We have now fabricated many hundreds of sensors, tested many of them, and they work. We have now also learned the art of bump- bonding, and have succeeded in bonding our sensor to our readout chip without bonding defects. We have designed, fabricated, debugged, tested, and characterized the CMOS readout chip, which is protected from X rays behind the sensor on three sides. The readout chip works, but we need to correct minor bugs in the design, and expand it to full size, during the next project period. Our detector discriminates individual X rays yet responds linearly to radiation levels approaching 400,000/s/pixel. Its point response lies within a single pixel. It reads out continuously with a 64mu s period. During the next stage of the project we will fabricate many full-scale sensor/ASIC module sandwiches, design and make a field-programmable gate array (FPGA) to control the module and interface it to a host computer, and design and implement an integrated system that includes controls software. In year 3 we will make our first practical system: a small array designed specifically for high-speed time-resolved small-angle X-ray diffraction of biological samples. In years 4-5 we will make a large detector system for protein crystallography that will incorporate between 900 -1,000 modules and cover an area of 30cm x 30cm.

描述（由申请人提供）：我们建议继续开发“3DX”硅像素阵列探测器，其中衍射X射线直接捕获在厚的高电阻率硅中，通过电感耦合等离子体蚀刻进行微加工。每个像素为150 x150 μ m，具有一个n型电极和一个p型电极，并且其通过导电（铟）凸块接合到位于传感器后面的CMOS读出芯片的相应像素。每个硅传感器是一个64 x64像素的阵列（总尺寸：9.6mmx9.6mm）。在我们的设计中，传感器晶片在最边缘都是有源的。因此，这些传感器的重叠阵列没有死间隙。我们现在已经制造了数百个传感器，测试了其中的许多传感器，它们都能工作。我们现在也已经学会了凸点键合的艺术，并成功地将我们的传感器键合到我们的读出芯片上，没有键合缺陷。我们已经设计，制造，调试，测试和表征的CMOS读出芯片，这是从X射线的传感器后面的三面保护。读出芯片工作，但我们需要纠正设计中的小错误，并在下一个项目期间将其扩展到全尺寸。我们的探测器可以分辨单个X射线，但对接近400，000/s/像素的辐射水平有线性响应。其点响应位于单个像素内。它以64 μ s的周期连续读出。在项目的下一阶段，我们将制作许多全尺寸的传感器/ASIC模块三明治，设计和制作一个现场可编程门阵列（FPGA）来控制模块和接口到主机，并设计和实现一个集成系统，包括控制软件。在第三年，我们将制作我们的第一个实用系统：一个专门为生物样品的高速时间分辨小角度X射线衍射设计的小阵列。在第4-5年，我们将制作一个用于蛋白质晶体学的大型探测器系统，该系统将包含900 - 1，000个模块，覆盖面积为30 cm x 30 cm。