The Florida Research Infrastructure Enhancement Plan

佛罗里达州研究基础设施增强计划

• 批准号: 6951978
• 负责人: Robert A Burne
• 金额: $ 145.5万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-24 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951978
• 关键词: cooperative study; dental personnel; dentistry; dentistry education; education evaluation /planning; educational resource design /development; health science manpower; health science research support; role model; training

DESCRIPTION (provided by applicant): In concert with highly qualified Internal and External Advisory committees, the University of Florida College of Dentistry (UFCD) has completed a comprehensive evaluation and Needs Assessment of our research programs. UFCD has identified a core group of basic and patient-oriented researchers upon which to build a broad-based, multidisciplinary research program that is capable of fully integrating basic and clinical oral health sciences with four major initiatives on the University of Florida campus and Health Sciences Center. A Research Infrastructure Enhance Plan has been developed that has the full support of UF and Health Science Center administration and provides a logical and sustainable strategy for creating a research enterprise that is capable of meeting the challenges of the NIDCR Strategic Plan and the NIH Roadmap. To achieve these goals, a single specific aim has been established: To implement a highly focused, realistic and achievable Research Infrastructure Enhancement Plan developed in response to a Needs Assessment by our Internal and External Advisory committees. The Plan has four primary components: a) Establish a Clinical and Translational Research enterprise that will complement existing basic science strengths at UFCD and with key clinical and basic science initiatives at University of Florida. b) Conduct targeted recruitments for two basic scientists to achieve critical mass in the area of Cell and Molecular Biology to underpin the Clinical and Translational program. c) Create a formal Training and Mentoring Structure that will fully support the research mission of the College during the transition through the Research Enhancement phase and will sustain the research enterprise of the College and Health Sciences Center in the long-term. d) Solidify linkages of the UFCD with four areas of excellence at the University of Florida - The Genetics Institute, the Diabetes Research groups, the Cancer Center, and the McKnight Brain Institute - and establish firm ties with the UF General Clinical Research Center.

描述(由申请人提供)：佛罗里达大学牙科学院(UFCD)与高素质的内部和外部咨询委员会合作，完成了对我们研究项目的全面评估和需求评估。UFCD已经确定了一批基础和以患者为导向的核心研究人员，以此为基础建立一个基础广泛的多学科研究计划，能够将基础和临床口腔健康科学与佛罗里达大学校园和健康科学中心的四项主要倡议完全结合起来。已经制定了一项研究基础设施增强计划，该计划得到了UF和健康科学中心管理部门的全力支持，并为创建能够应对NIDCR战略计划和NIH路线图挑战的研究企业提供了一个合乎逻辑和可持续的战略。为了实现这些目标，已经确立了单一的具体目标： 实施针对内部和外部咨询委员会的需求评估而制定的高度集中、切合实际和可实现的研究基础设施改进计划。该计划有四个主要组成部分： A)建立一个临床和转化研究企业，该企业将补充UFCD现有的基础科学优势，并与佛罗里达大学的关键临床和基础科学倡议相补充。 B)对两名基础科学家进行有针对性的招聘，以达到细胞和分子生物学领域的临界质量，以支持临床和翻译计划。 C)建立一个正式的培训和指导结构，在通过研究加强阶段的过渡期间全面支持学院的研究使命，并将长期支持学院和健康科学中心的研究事业。 D)巩固UFCD与佛罗里达大学四个卓越领域--遗传学研究所、糖尿病研究小组、癌症中心和麦克奈特脑研究所--的联系，并与UF综合临床研究中心建立牢固的联系。

项目成果

Innate immune receptor expression in peri-implant tissues of patients with different susceptibility to periodontal diseases.

• DOI: 10.1902/jop.2012.120061
• 发表时间: 2013-01
• 期刊: Journal of periodontology
• 影响因子: 4.3
• 作者: Theofilos Koutouzis;Dominick Catania;K. Neiva;S. Wallet

Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic Porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice.

粘液瘤病毒抗炎趋化因子结合蛋白可减少小鼠球囊血管成形术主动脉损伤后慢性牙龈卟啉单胞菌口腔感染引起的斑块生长增加。

• DOI: 10.1371/journal.pone.0111353
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Lucas,AlexandraR;Verma,RajK;Dai,Erbin;Liu,Liying;Chen,Hao;Kesavalu,Sheela;Rivera,Mercedes;Velsko,Irina;Ambadapadi,Sriram;Chukkapalli,Sasanka;Kesavalu,Lakshmyya
• 通讯作者: Kesavalu,Lakshmyya

Hyper-responsive phenotype in localized aggressive periodontitis.

• DOI: 10.1177/0022034509353397
• 发表时间: 2010-02
• 期刊: Journal of dental research
• 影响因子: 7.6
• 作者: Shaddox L;Wiedey J;Bimstein E;Magnuson I;Clare-Salzler M;Aukhil I;Wallet SM
• 通讯作者: Wallet SM

Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease.

• DOI: 10.1155/2010/605125
• 发表时间: 2010
• 期刊: Interdisciplinary perspectives on infectious diseases
• 作者: Verma RK;Rajapakse S;Meka A;Hamrick C;Pola S;Bhattacharyya I;Nair M;Wallet SM;Aukhil I;Kesavalu L
• 通讯作者: Kesavalu L

Virulence of major periodontal pathogens and lack of humoral immune protection in a rat model of periodontal disease.

牙周病大鼠模型中主要牙周病原体的毒力和体液免疫保护的缺乏。

• DOI: 10.1111/j.1601-0825.2010.01678.x
• 发表时间: 2010
• 期刊: Oral diseases
• 影响因子: 3.8
• 作者: Verma,RK;Bhattacharyya,I;Sevilla,A;Lieberman,I;Pola,S;Nair,M;Wallet,SM;Aukhil,I;Kesavalu,L
• 通讯作者: Kesavalu,L