NOVEL TREATMENTS OF LUPUS TARGETING TNF-SUPERFAMILY RECEPTORS ON B CELLS

针对 B 细胞上 TNF 超家族受体的狼疮新疗法

• 批准号: 7380409
• 负责人: Robert H Carter
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380409
• 关键词: NOVEL; TREATMENTS; LUPUS; TARGETING; TNF

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to identify TNF-family growth factor recpetors on the surface of B cells that can be developed as targets for therapeutic control of autoantibody production by B cells in systemic lupus. The specific aim that will utilize the GCRC examines the expression of the receptors for growth factors on the surface of B cells of lupus patients and controls (including both healthy controls and controls with other inflammatory Rheumatologic diseases). The results of these assays will be correlated with clinical parameters and with levels of growth factors in the serum. This requires phlebotomy (as approved by the UAB IRB) and storage of samples of serum. The GCRC will be utilized for phlebotomy on volunteers from all subpopulations. The blood will be processed by the investigators. An aliquot of serum in appropriate tubes and with labels will be stored in the GCRC failities. This will permit re-examination of other properties of the samples at a later date. In patients who give consent, these samples will also be available for other studies. There is no other facility in the University to see these volunteers to obtain their blood samples, and thus this project needs the GCRC facility for the space and personnel for drawing these blood samples.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是鉴定B细胞表面的TNF-家族生长因子受体，这些受体可以作为系统性狼疮中B细胞自身抗体产生的治疗控制的靶点。将利用GCRC的具体目的是检查狼疮患者和对照（包括健康对照和患有其他炎性风湿病的对照）的B细胞表面上生长因子受体的表达。这些测定的结果将与临床参数和血清中生长因子的水平相关。这需要采血（经UAB IRB批准）和储存血清样本。GCRC将用于所有亚群志愿者的静脉切开术。血液将由研究者处理。将适当试管中的等份血清和标签储存在GCRC失效中。这将允许在以后重新检查样品的其他特性。在提供知情同意的患者中，这些样本也可用于其他研究。在大学里没有其他设施可以看到这些志愿者获得他们的血液样本，因此这个项目需要GCRC设施的空间和人员来抽取这些血液样本。